Reactions of 1,1-Disubstituted Alkenes with Acetoacetamides and Molecular Oxygen in the Presence of Manganese(III) Acetate

Article abstract of DOI:10.1246/bcsj.64.3557

The reactions of 1,1-disubstituted ethenes with acetoacetamide or N-substituted acetoacetamides, and molecular oxygen in the presence of manganese(III) acetate gave a mixture of c-4- and t-4-carbamoyl-3-methyl-1,2-dioxan-r-3-ols in good yields.Effects of substituents in the alkenes as welle as in the carbamoyl group in the acetoacetamides were observed.Stereochemistry and the reactivity of the 4-carbamoyl-3-methyl-1,2-dioxan-3-ols are discussed.