Turkish Journal of Chemistry p. 367 - 382 (2012)
Update date:2022-08-05
Topics: Synthesis Anti-Inflammatory Antiplatelet In Silico Evaluations
Baytas, Sultan
Turan Dural, Niludie Nermin
Oezkan, Yesim
Simsek, Hasan Bolkan
Guersel, Tuerkiz
Uenlue, Serdar
A series of (E) -3-(3-(2,3-dihydro-3-methyl-2-oxo-3H -benzoxazole-6-yl)-1- phenyl-1H -pyrazole-4-yl)acrylamides (7a-k) were synthesized and ealuated for their in itro inhibitory actiities on COX-1 and COX-2 isoforms using a human whole blood assay as well as their antiplatelet profile against human platelet aggregation using arachidonic acid as agonists. Among the synthesized deriaties 7a-k, especially compound 7g exhibited dual anti-inflammatory and antiplatelet actiity with selectie COX-2 inhibition. TUeBITAK.
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