Tetrahedron Letters p. 6537 - 6540 (1994)
Update date:2022-08-05
Topics: Lithium Enolates Efficient Synthesis 1,2-epoxides Catalyzed addition
Crotti, Paolo
Di Bussolo, Valeria
Favero, Lucilla
Macchia, Franco
Pineschi, Mauro
A simple, efficient method is described for the synthesis of γ-hydroxy ketones by the direct opening of 1,2-epoxides with lithium enolates derived from simple ketones in anhydrous toluene, in the presence of Y(OTf)3.
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