Journal of Medicinal Chemistry p. 1001 - 1018 (2018)
Update date:2022-08-15
Topics:
Helal, Christopher J.
Arnold, Eric
Boyden, Tracey
Chang, Cheng
Chappie, Thomas A.
Fisher, Ethan
Hajos, Mihaly
Harms, John F.
Hoffman, William E.
Humphrey, John M.
Pandit, Jayvardhan
Kang, Zhijun
Kleiman, Robin J.
Kormos, Bethany L.
Lee, Che-Wah
Lu, Jiemin
Maklad, Noha
McDowell, Laura
McGinnis, Dina
O'Connor, Rebecca E.
O'Donnell, Christopher J.
Ogden, Adam
Piotrowski, Mary
Schmidt, Christopher J.
Seymour, Patricia A.
Ueno, Hirokazu
Vansell, Nichole
Verhoest, Patrick R.
Yang, Edward X.
Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core to yield compounds of significantly enhanced potency. The analog PF-05180999 (30) was subsequen
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