Medicinal Chemistry Research p. 1825 - 1836 (2013)
Update date:2022-09-26
Topics:
Chowdhury, Sultan
Liu, Shifeng
Cadieux, Jay A.
Hsieh, Tom
Chafeev, Mikhail
Sun, Shaoyi
Jia, Qi
Sun, Jianyu
Wood, Mark
Langille, Jonathan
Sviridov, Serguei
Fu, Jianmin
Zhang, Zaihui
Chui, Ray
Wang, Audrey
Cheng, Xing
Zhong, Jing
Hossain, Sazzad
Khakh, Kuldip
Rajlic, Ivana
Verschoof, Henry
Kwan, Rainbow
Young, Wendy
The structure-activity relationship of a new series of tetracyclic spirooxindoles led to the discovery of compound 25a, a potent hNaV1.7 blocker with improved ADME properties and in vivo efficacy in the CFA-induced inflammatory pain model.
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