Rapid construction of the aza-propellane core of acutumine via a photochemical [2 + 2] cycloaddition reaction

Article abstract of DOI:10.1021/ol3017963

Synthetic efforts toward the chlorinated aza-propellane alkaloid acutumine (1) are described. The key vicinal quaternary centers were constructed by a photochemical [2 + 2] cycloaddition reaction of a furanyl-tetrahydroindolone. Dihydroxylation of the [2