N-Alkylated 2-trifluoromethyl-4-quinolones by addition of base and an alkylating agent to 2-trifluoroacetylaminoacetophenones

Article abstract of DOI:10.1080/00397919208021309

2-Trifluoroacetylaminoacetophenones 1 are cyclized to N-alkyl-2-trifluoromethyl-4-quinolones 2 in one pot with concomitant N-alkylation in 40 to 74% yield using potassium hydroxide in acetone containing an alkylating agent.

Full text of DOI:10.1080/00397919208021309

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Synthetic Communications: An
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Communication of Synthetic
Organic Chemistry
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N-Alkylated 2-
Trifluoromethyl-4-quinolones
by Addition of Base and
an Alkylating Agent to 2-
Trifluoroacetylaminoacetophenone
Donald W. Combs a , Marianne S. Reed a & Dieter H.
Klaubert a
a The R. W. Johnson Pharmaceutical Research
institute , Route 202, P.O. Box 300, Raritan, NJ,
08869-0602
Published online: 23 Sep 2006.
To cite this article: Donald W. Combs , Marianne S. Reed & Dieter H. Klaubert (1992)
N-Alkylated 2-Trifluoromethyl-4-quinolones by Addition of Base and an Alkylating
Agent to 2-Trifluoroacetylaminoacetophenones, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 22:2,
323-326, DOI: 10.1080/00397919208021309
To link to this article: http://dx.doi.org/10.1080/00397919208021309
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