Synthesis of α-vinylidene-β-lactams by the palladium-catalyzed carbonylation of 4-amino-2-alkynyl carbonates

Article abstract of DOI:10.1016/0040-4039(91)80564-M

The palladium-catalyzed carbonylation of 4-amino-2-alkynyl carbonates proceeded under mild conditions to afford α-vinylidene-β-lactams in moderate yields. The cyclic phosphite, 4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2,2,2]octane was found to be the best li