Ortho Substituent effects on the anticonvulsant properties of 4-hydroxy-trifluoroethyl phenols

Article abstract of DOI:10.1016/j.bmcl.2012.07.001

2,6-Dialkylphenols with isopropyl and sec-butyl substituent are well known anesthetic compounds. The 4-substitution with 1-hydroxy-2,2,2-trifluoroethyl (4-HTFE) group in these compounds led to the discovery of compounds with anticonvulsant activity in the