Crucial role of 3-bromoethyl in removing the estrogenic activity of 17β-HSD1 inhibitor 16β-(m-carbamoylbenzyl)estradiol

DOI: 10.1021/ml200093v

Source and publish data:

ACS Medicinal Chemistry Letters p. 678 - 681 (2011)

Update date:2022-08-04

Topics:

Authors:

Maltais, Rene

Ayan, Diana

Poirier, Donald

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Article abstract of DOI:10.1021/ml200093v

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) represents a promising therapeutic target for breast cancer treatment. To reduce the undesirable estrogenic activity of potent 17β-HSD1 inhibitor 16β-(m-carbamoylbenzyl)estradiol (1) (IC₅₀ = 27

Full text of DOI:10.1021/ml200093v

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