New potential prodrugs of aciclovir using calix[4]arene as a lipophilic carrier: Synthesis and drug-release studies at the air-water interface

Article abstract of DOI:10.1039/c2nj40338b

Two tetra-p-tert-butyl-calix[4]arene species bearing one or two anti-HSV aciclovir units tethered via carbodiester linkages at the lower rim were synthesized as possible antiviral prodrugs. The amphiphilic properties of these derivatives were studied usin

Full text of DOI:10.1039/c2nj40338b

Electronic Supplementary Material (ESI) for New Journal of Chemistry
This journal is © The Royal Society of Chemistry and The Centre National de la Recherche Scientifique 2012
Electronic supplementary information
New potential prodrugs of aciclovir using calix[4]arene as lipophilic carrier:
synthesis and drug-release studies at the air-water interface
Guillaume Sautrey,a Igor Clarot,a Ewa Rogalska,a Jean-Bernard Regnouf-de-
Vainsa*
a Université de Lorraine, SRSMC, UMR 7565 CNRS; équipe GEVSM, Faculté de Pharmacie, 5, rue Albert Lebrun, 54001
Nancy cedex, France. E-mail: jean-bernard.regnouf@pharma.uhp-nancy.fr;
Fax: +33 3 83 68 23 45; Tel: +33 3 83 68 23 15
Table of content
HPLC accuracy
Table T1
Table 1 Precision and accuracy of the HPLC-UV analytical procedure (n = 3 on three
days) with solutions of aciclovir in carbonate buffer treated according to the ST
procedure.
Precision
(RSD %)
2.6
Accuracy
(%)
100.9 ± 1.6
98.7 ± 2.7
105.1 ± 2.6
SST(10
Day 1
Day 2
Day 3
1.5
2.3
Intermediate precision
3.0
SST(40)
SST(100)
Day 1
Day 2
Day 3
Intermediate precision
Day 1
Day 2
Day 3
1.4
0.2
1.4
2.8
0.5
0.5
0.5
103.9 ± 0.5
100.5 ± 1.4
106.4 ± 1.5
105.5 ± 0.6
99.9 ± 0.5
96.2 ± 1.0
Intermediate precision
4.0
1