ChemCatChem p. 2692 - 2697 (2014)
Update date:2022-07-29
Topics:
Hung, Chen-Hsun
Gandeepan, Parthasarathy
Cheng, Chien-Hong
An efficient and atom-economical method for the synthesis of substituted indenamines from N-tosylarylimines and alkynes via ruthenium(II)-catalyzed C-H bond activation and annulation is described. The catalytic reaction proceeds well with a broad substrate scope and in good yields. A possible mechanism is proposed that involves imine nitrogen chelation-assisted ortho-C-H bond activation of the substrate, alkyne insertion, and intramolecular insertion of the C£ NTs group into the C-Ru bond. Isotope-labeling experiments are performed to understand the underlying mechanism of the reaction. Atomic bean counters succeed! An efficient and atom-economical method for the synthesis of substituted indenamines from N-tosylarylimines and alkynes via ruthenium(II)-catalyzed C-H bond activation and annulation is described.
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