A synthesis of 2-substituted 2-aminoethanol derivatives having inhibitory activity against protein kinase C

DOI: 10.1248/cpb.40.122

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 122 - 126 (1992)

Update date:2022-08-05

Topics:

Authors:

Iwasaki Iwasaki

Yamazaki

Nishitani

Kondo Kondo

Sato Sato

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Article abstract of DOI:10.1248/cpb.40.122

A series of 2-aminoethanol derivatives was synthesized and their inhibitory activities against protein kinase C were investigated. Among these compounds, 2-endo-hexadecylamino-5-norbornene-2-exo-methanol (4h) and 2-endohexadecylamino-5-norbornene-2,3-exo-dimethanol (4i) inhibited protein kinase C at the IC₅₀ values of 2 x 10^-5 and 1 x 10^-5 M, respectively, but not protein kinase A at a concentration of 1 x 10^-3 M. The structure-activity relationships are discussed.

Full text of DOI:10.1248/cpb.40.122

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