Chemical and Pharmaceutical Bulletin p. 122 - 126 (1992)
Update date:2022-08-05
Topics:
Iwasaki
Yamazaki
Nishitani
Kondo
Sato
A series of 2-aminoethanol derivatives was synthesized and their inhibitory activities against protein kinase C were investigated. Among these compounds, 2-endo-hexadecylamino-5-norbornene-2-exo-methanol (4h) and 2-endohexadecylamino-5-norbornene-2,3-exo-dimethanol (4i) inhibited protein kinase C at the IC50 values of 2 x 10-5 and 1 x 10-5 M, respectively, but not protein kinase A at a concentration of 1 x 10-3 M. The structure-activity relationships are discussed.
View MoreShanghai Mio Chemical Co., Ltd
Contact:0086 21- 64401188-622
Address:16 Floor NO.2 Jiefang Building, No. 4855 Dushi Road, 201100 Shanghai, P.R.China
Contact:86-931-8272767
Address:Room 602, No.461, Nanchang Road, Chengguan District, Lanzhou City, China PRC
Shanghai Micro-mega Industry Co., Ltd.
Contact:0086-21-34628682;57153848
Address:Rm413,No.413,West Meilong Road, Minhang District,Shanghai P R China
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.
website:http://www.zyterpharm.com
Contact:+86-18858184290
Address:West Wenyi Road, Cangqian, Yuhang
Zhejiang Chemicals Import & Export Corporation
Contact:86-571-87043088
Address:No.37,Qingchun Road,Hangzhou,China
Doi:10.1002/poc.2939
(2012)Doi:10.1016/j.tet.2015.05.110
(2015)Doi:10.1039/c5dt02226f
(2015)Doi:10.1080/10426500701758421
(2008)Doi:10.2298/JSC111001023J
(2012)Doi:10.1021/jm00074a007
(1993)
