Chemical and Pharmaceutical Bulletin p. 122 - 126 (1992)
Update date:2022-08-05
Topics:
Iwasaki
Yamazaki
Nishitani
Kondo
Sato
A series of 2-aminoethanol derivatives was synthesized and their inhibitory activities against protein kinase C were investigated. Among these compounds, 2-endo-hexadecylamino-5-norbornene-2-exo-methanol (4h) and 2-endohexadecylamino-5-norbornene-2,3-exo-dimethanol (4i) inhibited protein kinase C at the IC50 values of 2 x 10-5 and 1 x 10-5 M, respectively, but not protein kinase A at a concentration of 1 x 10-3 M. The structure-activity relationships are discussed.
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(1993)
