Journal of Medicinal Chemistry p. 3274 - 3277 (1993)
Update date:2022-08-05
Topics:
Baures, Paul W.
Eggleston, Drake S.
Erhard, Karl F.
Cieslinski, Lenora B.
Torphy, Theodore J.
Christensen, Siegfried B.
Chiral HPLC resolution of the phosphodiesterase IV (PDE IV) inhibitor rolipram (1) provided (-)-1, and this enantiomer was converted into its 1-(4-bromobenzyl) derivative, (+)-2.X-ray structural analysis of (+)-2 establishad the absolute configuration as
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