Organic process research and development p. 85 - 91 (2010)
Update date:2022-08-04
Topics:
Adolph, Sven
Laue, Klaus
Roeder, Michael
Walker, Andrew J.
Connell, Richard B.
Watson, John
Rueggeberg, Carsten J.
Voegtli, Kurt
Hahn, Dirk Uwe
Control of trace inorganics and an understanding of reaction kinetics and impurity generation proved critical in allowing safe and reliable scale-up of a high-temperature Claisen reaction in support of multikilogram manufacture of a key chromene intermediate 4. Implementation of a Medicinal Chemistry route allowed for rapid early phase delivery of 1 to support early clinical studies.
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