Selective Reversible and Irreversible Ligands for the κ Opioid Receptor

DOI: 10.1021/jm00090a015

Source and publish data:

Journal of Medicinal Chemistry p. 2243 - 2247 (1992)

Update date:2022-08-05

Topics:

Authors:

Cheng, Chen-Yu

Wu, Shou-Chien

Hsin, Ling-Wei

Tam, S. William

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Article abstract of DOI:10.1021/jm00090a015

(+/-)-(5β,7α,8β)-3,4-Dichloro-N-methyl-N-<3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro<4,5>dec-7-yl>benzeneacetamide (14) and its (5α,7α,8β) diastereomer 15 have been synthesized from 1,4-cyclohexanedione monoethylene ketal (1) in 10 steps.Compound 14,

Full text of DOI:10.1021/jm00090a015

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