Journal of Medicinal Chemistry p. 2243 - 2247 (1992)
Update date:2022-08-05
Topics:
Cheng, Chen-Yu
Wu, Shou-Chien
Hsin, Ling-Wei
Tam, S. William
(+/-)-(5β,7α,8β)-3,4-Dichloro-N-methyl-N-<3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro<4,5>dec-7-yl>benzeneacetamide (14) and its (5α,7α,8β) diastereomer 15 have been synthesized from 1,4-cyclohexanedione monoethylene ketal (1) in 10 steps.Compound 14,
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