Highly Diastereoselective Alcoholysis of ?-Symmetric Dicarboxylic Acid Anhydrides Using 1-Phenyl-3,3-bis(trifluoromethyl)propan-1,3-diol

DOI: 10.1246/cl.1992.389

Source and publish data:

Chemistry Letters p. 389 - 392 (1992)

Update date:2022-08-03

Topics:

Authors:

Suda, Yoshimitsu

Yago, Seiji

Shiro, Motoo

Taguchi, Takeo

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Article abstract of DOI:10.1246/cl.1992.389

Highly diastereoselective alcoholysis of ?-symmetric dicarboxylic acid anhydrides was performed using 1-phenyl-3,3-bis(trifluoromethyl)propan-1,3-diol.The importance of the geminally trifluoromethylated carbinol moiety for achieving a high degree of chiral induction was confirmed from lower diastereoselectivity with the hydroxyl protected 1,3-diol or with the similar 1,3-diols having hydrocarbon substituents instead of the trifluoromethyl group.

Full text of DOI:10.1246/cl.1992.389

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