Highly Diastereoselective Alcoholysis of ?-Symmetric Dicarboxylic Acid Anhydrides Using 1-Phenyl-3,3-bis(trifluoromethyl)propan-1,3-diol

Article abstract of DOI:10.1246/cl.1992.389

Highly diastereoselective alcoholysis of ?-symmetric dicarboxylic acid anhydrides was performed using 1-phenyl-3,3-bis(trifluoromethyl)propan-1,3-diol.The importance of the geminally trifluoromethylated carbinol moiety for achieving a high degree of chiral induction was confirmed from lower diastereoselectivity with the hydroxyl protected 1,3-diol or with the similar 1,3-diols having hydrocarbon substituents instead of the trifluoromethyl group.