Carbohydrates as chiral templates: Stereoselective synthesis of (R)- and (S)-α-aminophosphonic acid derivatives

Article abstract of DOI:10.1055/s-1992-34155

The stereoselective synthesis of diethyl (S)- or (R)-α-[(O-pivaloyl-hexapyranosyl)amino]benzylphosphonates is achieved via Lewis acid catalyzed addition of diethyl phosphite to O-pivaloylated N-benzylidene-β-D-galactosylamine or N-benzylidene-α-D-arabinop