The First Asymmetric Total Synthesis of Thienamycin-like γ-Lactam and its Analogue

DOI: 10.1039/c39920000437

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 437 - 439 (1992)

Update date:2022-09-26

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Authors:

Nagao, Yoshimitsu

Matsunaga, Hiroshi

Kumagai, Toshio

Inoue, Yoshinori

Miwa, Yoshihisa

Taga, Tooru

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Article abstract of DOI:10.1039/c39920000437

The asymmetric total synthesis of thienamycin-like γ-lactam 1 and its analogue 2 has been accomplished by utilising highly diastereoselective alkylation of tin(II) enolate 5 on acyl imine obtained in situ from chiral 3-substituted 5-acetoxypyrrolidin-2-on

Full text of DOI:10.1039/c39920000437

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