Journal of Agricultural and Food Chemistry p. 325 - 330 (1975)
Update date:2022-08-03
Topics:
Greenhalgh
Kovacicova
The effects of different solvents and temperatures on the base catalyzed reaction of O,O-diethyl N-methyl phosphoramidothioate and methyl iodide were studied. The N-methyl derivative was obtained in high yield in dimethyl sulfoxide at 50° for 10 min with sodium hydride as the base. This alkylation procedure was adapted to the microgram level and applied to 16 insecticides and herbicides which have an NH or NH2 moiety. With carbamates, the best yields were obtained when the reaction was carried out at room temperature. The alkylated derivatives of organophosphorus and carbamate insecticides and triazine and urea herbicides all had better gc characteristics than the parent compounds. Thus, the alkylureas readily chromatographed on SE-30/QF-1 under conditions where the parent compounds decomposed. On this column, the alkylated phosphoramidothioates and carbamates also had shorter retention times. Alkylation of crude extracts of soil, plants, and blood plasma containing herbicides and insecticides illustrated the ability of the sodium hydride methyl iodide dimethyl sulfoxide procedure to confirm the identity of residues at the sub parts per million level.
View MoreSHANDONG AONA CHEMICAL CO.,LTD.
Contact:86-532-85762926
Address:LIUYUAN TOWN, ZAOZHUANG CITY, SHANGDONG PROVINCE.
QINGDAO HONG JIN CHEMICAL CO.,LTD.
website:http://www.hongjinchem.com
Contact:+86-532-83657313
Address:2ND Building, 8 Shangqing Road, Qingdao, Shandong Province, China.
Rizhao Lanxing Chemical Indusrial Co.,Ltd
Contact:86-633-2616708
Address:NO.15 West road Shenglan, Lanshan district, Rizhao City
Contact:0086-22-2822 1962 / 2822 1963
Address:B-808, No. 1, North-South Street, Hexi District,
Shanghai Kangxin Chemical Co., Ltd
Contact:+86 21 60717227
Address:118,Ganbai Village,Waigang Town,Jiading District,Shanghai
Doi:10.1021/jo01270a051
(1968)Doi:10.1111/cbdd.12686
(2016)Doi:10.1080/00397919508011770
(1995)Doi:10.1080/15257779508014659
(1995)Doi:10.1016/j.chembiol.2019.03.008
(2019)Doi:10.1016/S0040-4039(00)76871-7
(1994)