Journal of Agricultural and Food Chemistry p. 325 - 330 (1975)
Update date:2022-08-03
Topics:
Greenhalgh
Kovacicova
The effects of different solvents and temperatures on the base catalyzed reaction of O,O-diethyl N-methyl phosphoramidothioate and methyl iodide were studied. The N-methyl derivative was obtained in high yield in dimethyl sulfoxide at 50° for 10 min with sodium hydride as the base. This alkylation procedure was adapted to the microgram level and applied to 16 insecticides and herbicides which have an NH or NH2 moiety. With carbamates, the best yields were obtained when the reaction was carried out at room temperature. The alkylated derivatives of organophosphorus and carbamate insecticides and triazine and urea herbicides all had better gc characteristics than the parent compounds. Thus, the alkylureas readily chromatographed on SE-30/QF-1 under conditions where the parent compounds decomposed. On this column, the alkylated phosphoramidothioates and carbamates also had shorter retention times. Alkylation of crude extracts of soil, plants, and blood plasma containing herbicides and insecticides illustrated the ability of the sodium hydride methyl iodide dimethyl sulfoxide procedure to confirm the identity of residues at the sub parts per million level.
View MoreNanjing Samwon International Limited
Contact:+86-25-84873444
Address:1108, BLDG B, New Century Plaza, No 1, South Taiping Rd.,
Nantong Kaixin Pharma Chemical Co.,Ltd.
Contact:86-513-85250786
Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
Shenzhen HwaGen Pharmaceutical Co., Ltd
website:http://www.rafflespt.com
Contact:+86-752-5538396
Address:Guangdong Huizhou China
Contact:+86-571-28186845
Address:Room 1224,Eastcom Mansion,398 Wensan Road,Hangzhou,310013 China
Taizhou volsen chemical Co., Ltd
website:http://www.volsenchem.com
Contact:+86-576-88869393
Address:Jiaojiang District, Taizhou, Zhejiang, China.
Doi:10.1021/jo01270a051
(1968)Doi:10.1111/cbdd.12686
(2016)Doi:10.1080/00397919508011770
(1995)Doi:10.1080/15257779508014659
(1995)Doi:10.1016/j.chembiol.2019.03.008
(2019)Doi:10.1016/S0040-4039(00)76871-7
(1994)