Erythroselective aldol condensation of amine free 2-t-butyl-5-methyl-2-phenyl-1,3-dioxolan-4-one lithium enolate synthesis of the ethyl acetolactate enantiomers

Article abstract of DOI:10.1016/S0040-4039(00)74171-2

Generated by halogen metal exchange, the sterically hindered 2-t-butyl-5-methyl-2-phenyl-1,3-dioxolan-4-one lithium enolate reacts in an erythroselective way with acetaldehyde. Separation of the resulting diastereomers, followed by alcoholysis lead to the