Bioorganic and Medicinal Chemistry Letters p. 2349 - 2352 (1997)
Update date:2022-08-04
Topics:
Shimada, Junichi
Koike, Nobuaki
Nonaka, Hiromi
Shiozaki, Shizuo
Yanagawa, Koji
Kanda, Tomoyuki
Kobayashi, Hiroyuki
Ichimura, Michio
Nakamura, Joji
Kase, Hiroshi
Suzuki, Fumio
Structure-activity relationships of 8-styrylxanthines for in vivo adenosine A(2A) antagonism were explored. Diethyl substitution both at the 1- and S-position was found to dramatically potentiate the anti-cataleptic activity.
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