Adenosine A(2A) antagonists with potent anti-cataleptic activity

DOI: 10.1016/S0960-894X(97)00440-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2349 - 2352 (1997)

Update date:2022-08-04

Topics:

Authors:

Shimada, Junichi

Koike, Nobuaki

Nonaka, Hiromi

Shiozaki, Shizuo

Yanagawa, Koji

Kanda, Tomoyuki

Kobayashi, Hiroyuki

Ichimura, Michio

Nakamura, Joji

Kase, Hiroshi

Suzuki, Fumio

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Article abstract of DOI:10.1016/S0960-894X(97)00440-X

Structure-activity relationships of 8-styrylxanthines for in vivo adenosine A(2A) antagonism were explored. Diethyl substitution both at the 1- and S-position was found to dramatically potentiate the anti-cataleptic activity.

Full text of DOI:10.1016/S0960-894X(97)00440-X

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