Studies on the synthesis of strychnos indole alkaloids. An efficient stereocontrolled synthetic route to 2,4,8- and 2,8,9-trisubstituted 2-azabicyclo[3.3.1]nonan-7-ones

Article abstract of DOI:10.1016/0040-4039(92)88140-Z

A stereocontrolled four-step synthesis of polysubstituted functionalized morphans 7 and 8 from the 3,4-cis piperidine derivative 1 is reported. β-Keto ester 1 was converted to 4-(oxopentyl)piperidines 3, and then to the 2-cyano derivatives 4 and 5, which