A new approach to the solid-phase peptide synthesis of peptide alkyl-amides and esters

DOI: 10.1016/0040-4039(92)88172-2

Source and publish data:

Tetrahedron Letters p. 2183 - 2186 (1992)

Update date:2022-08-04

Topics:

Authors:

Nicolas Nicolas

Clemente

Perello Perello

Albericio

Pedroso Pedroso

Giralt Giralt

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Article abstract of DOI:10.1016/0040-4039(92)88172-2

The use of the α-(4-hydroxymethyl-3-nitrobenzamido)benzylpolystyrene (4-hydroxymethyl-Nbb resin) to obtain peptide esters and amides is reported. The lability of the peptide-resin bond to methanol, methylamine, dimethylamine and hexylamine has been tested on three peptidyl-resin models with encouraging results.

Full text of DOI:10.1016/0040-4039(92)88172-2

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