Palladium Catalyzed, Multicomponent Synthesis of Fused-Ring Pyrroles from Aryl Iodides, Carbon Monoxide, and Alkyne-Tethered Imines

Article abstract of DOI:10.1021/acs.joc.6b02102

A palladium-catalyzed multicomponent route to polycyclic pyrroles is described. Pd(P^tBu₃)₂ was found to catalyze the coupling of (hetero)aryl iodides, two equivalents of carbon monoxide and alkyne-tethered imines into 1,3-

Full text of DOI:10.1021/acs.joc.6b02102

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Article
Paladium Catalyzed Multicomponent Synthesis of Fused-Ring Pyrroles
from Aryl Iodides, Carbon Monoxide and Alkyne-Tethered Imines
Neda Firoozi, Gerardo Martin Torres, and Bruce A. Arndtsen
J. Org. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.joc.6b02102 • Publication Date (Web): 11 Oct 2016
Downloaded from http://pubs.acs.org on October 14, 2016
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Palladium Catalyzed, Multicomponent Synthesis of Fused-Ring Pyrroles from Aryl Iodides, Carbon
Monoxide and Alkyne-Tethered Imines
Neda Firoozi,‡† Gerardo M. Torres,‡ and Bruce A. Arndtsen‡*
*‡Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, H3A 0B8
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Canada
†Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, 9177948974
Iran
bruce.arndtsen@mcgill.ca
RECEIVED DATE (will be automatically inserted after manuscript is accepted).
Abstract: A palladium-catalyzed multicomponent route to polycyclic pyrroles is described. Pd(PtBu3)2
was found to catalyze the coupling of (hetero)aryl iodides, two equivalents of carbon monoxide and
alkyne-tethered imines into 1,3-dipoles (Münchnones), which undergo spontaneous, intramolecular 1,3-
dipolar cycloaddition to form polycyclic pyrroles. The systematic variation of the alkyne, tethered-imine,
or aryl iodide can allow the build-up of a range of pyrrole derivatives, where any of the substituents can be
independently varied. In addition, the same palladium catalyst can be employed in an initial Sonogashira-
type coupling with aryl iodides, which upon the addition of CO can allow the novel tandem catalytic, five
component synthesis of diversely substituted products.
Introduction
Polycyclic pyrroles and their derivatives are a common motif in natural products and pharmaceutical
design.1 While a range of methods have been developed to synthesize pyrroles, including cyclization
strategies (e.g. Paal-Knorr synthesis),2 or substitution chemistry on preformed pyrroles (e.g. cross coupling
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or C-H bond functionalization),3 the design of routes to polycyclic variants of these products that do not
require the initial assembly of highly substituted precursors has been less developed. One useful approach
to these products and their derivatives is via the intramolecular cycloaddition of alkynes or alkenes to
Münchnones (Scheme 1a).4 This transformation has been exploited by a number of research laboratories,
including in targeted synthesis.5 However, as with many routes to these heterocycles, this chemistry
typically entails the build-up of the carboxylic acid precursor to Münchnones prior to dehydration and
cycloaddition.
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Scheme 1. 1,3-Dipolar Cycloaddition Routes to Polycyclic Pyrrole Derivatives
In considering the design of more streamlined routes to these products, we have recently reported that
the palladium-catalyzed carbonylation of aryl iodides in the presence of imines can provide a method to
construct Münchnones (Scheme 1b).6 This transformation can be coupled with subsequent addition of
alkynes for cycloaddition to provide an overall multicomponent synthesis of substituted pyrroles. A useful
feature of this reaction is the availability of imine, alkyne, aryl iodide building blocks, each of which is
either commercially available, inexpensive, or easily formed. In light of these features, we questioned if
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this reaction could be extended to assemble even more complex scaffolds such as polycyclic products with
minimal synthetic effort. For example, alkyne-tethered imines are easily synthesized from 2-substituted
aromatic aldehydes with amines,7 and upon use in the palladium catalyzed multicomponent formation of
Münchnones would allow the straightforward assembly polycyclic pyrroles in a single operation from
combinations of available substrates (Scheme 1c). A facet of this chemistry would be the presence of the
alkyne in the imine substrate, which may allow the use of less activated alkynes to be employed in the
Münchnone cycloaddition reaction, and therefore broaden the scope of this transformation.
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We describe here our studies toward the design of this palladium-catalyzed route to synthesize fused-
ring pyrroles. This can provide an efficient and modular route to these products from building blocks that
are both accessible and can be generalized. In addition, this same palladium catalyst can also be employed
to derivatize the alkyne in a novel tandem catalytic approach to generate highly substituted polycyclic
pyrroles.
Results and Discussion
Our previous research has shown that Pd(PtBu3)2 in concert with a chloride source can allow the
carbonylation of aryl iodides with imine nucleophiles into Münchnones via two sequential catalytic
reactions. This involves an initial in situ generation of acid chlorides, which can react with imine to form
N-acyl iminium salt intermediates for a subsequent palladium-catalyzed cyclocarbonylation to 2 (Scheme
2).6,8 In principle, the incorporation of an alkyne-tethered substrate into either on the aryl iodide or imine
should allow for spontaneous cycloaddition to generate 3. A requirement for the success of this reaction
will be the compatibility of the alkyne with both the palladium catalyzed carbonylations, and with the
imine substrate. For example, Münchnone cycloaddition typically required electron poor dipolarophiles,
which are not typically stable in the presence of nucleophilic imines, and have to be added after catalysis
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to generate pyrroles. Similarly, alkynes are viable insertion substrates, which could also lead to undesired
products.
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Scheme 2. Mechanism of the Pd-Catalyzed Carbonylative Synthesis of Münchnones
Our first studies involved the use of ortho-alkyne-tethered aryl iodides.9 This resulted in the formation
of a complex mixture of products with a number of catalyst systems potentially arising from the insertion
of the alkyne during the initial carbonylation of the aryl iodide (see Table S1 for details). In order to limit
this possibility, we moved to the analogous reaction of an alkyne-tethered imine 1a (Table 1), which can
be readily generated in two steps from salicylaldehyde. We were pleased to find that this latter imine in
concert with p-iodotoluene, CO, and Pd(allyl)Cl/PtBu3 catalyst leads to the clean formation of pyrrole 3a
(entry 1). Of note, the unactivated alkyne in 1a undergoes spontaneous cycloaddition under the palladium
catalyzed conditions, and does not appear to participate in insertion of other off-cycle processes. The
phosphine ligand plays an important role in the efficiency of this reaction. For example, PPh3 and PCy3
completely inhibit catalysis (entries 4, 5), while more sterically encumbered ligands allow the reaction to
proceed, albeit in lower yields than with PtBu3 (entries 6-9). This is consistent with our previous studies,10
which showed that the steric bulk of this phosphine is critical to both mediate strain induced acid
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Table 1. Catalyst Design for the Carbonylative Synthesis of 3a.a
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Yield
Entry
Pd cat.
Ligand
(%)b
70
0
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6
[Pd(allyl)Cl]2
[Pd(allyl)Cl]2
Pd2dba3.CH3Cl
[Pd(allyl)Cl]2
[Pd(allyl)Cl]2
[Pd(allyl)Cl]2
PtBu3
-
-
PCy3
PPh3
P(o-tolyl)3
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0
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[Pd(allyl)Cl]2
[Pd(allyl)Cl]2
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9
[Pd(allyl)Cl]2
5% Pd(PtBu3)2
40
76c,d
10
-
1a (6 mg, 0.03 mmol), 4-iodotoluene (33 mg, 0.15
mmol), Pd (0.003 mmol), L (0.009 mmol) Bu4NCl
(8 mg, 0.03 mmol), NEtiPr2 (6 mg, 0.045 mmol), CO
(4 atm), CD3CN. NMR yield. c0.5 mmol scale with
b
5 mol% Pd(PtBu3)2 (13 mg, 0.025 mmol), Bu4NCl
(139 mg, 0.5 mmol), 10 atm CO. dIsolated yield.
chloride reductive elimination, and remain sufficiently labile (due to its size) to allow carbonylation of 4
(Scheme 2). The optimized catalyst system with 5 mol% Pd(PtBu3)2 and Bu4NCl allows the synthesis of 3
in good overall yield (76%, entry 10).
A feature of this platform is its ease of diversification. As examples, a number of different alkyne units
can be readily incorporated into 1 and participate in cycloaddition to form pyrroles (3a-c). This includes
internal alkynes, phenylacetylene derivatives and even terminal alkynes. The use of terminal alkynes is
notable, as Sonogashira coupling with the aryl iodide is also a viable reaction pathway (vide infra). Both
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N-alkyl and –benzyl imines are compatible with this reaction, as are functionalities on the aromatic
backbone (3i). However, potentially coordinating substrates such as those with nitrogen-containing tethers
are not viable substrates.11 An even broader array of aryl iodides can be incorporated into this
transformation as a method to tune the 2-position of the heterocycle. Electron rich (3b, c, f, g), electron
poor (3j-l, n), and simple aryl iodides (3m) are compatible with the reaction conditions, and lead to the
formation of pyrroles in good overall yields. This includes para- (3a-l), meta- (3n,o), and disubstituted
(3p,q) aromatic residues. However, ortho-substituted aryl iodides do not lead to products under these
conditions. This chemistry can also be extended to use of heteroaryl iodides, such as thiophenyl iodide
(3r) and 5-iodoindoles (3s). These latter provide facile access to heteroaryl-substituted pyrroles.
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Table 2. Palladium-Catalyzed Polycyclic Pyrrole Synthesisa
Aryl
Iodide
Aryl
Iodide
Imine
Product 3b
Imine
Product 3b
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aGeneral: 1 (0.5 mmol), 2 (2.5 mmol), Pd(PtBu3)2 (13 mg, 0.025 mmol), Bu4NCl (139 mg, 0.5 mmol), NEtiPr2 (97
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b
mg, 0.75 mmol), CO (10 atm) in CH3CN, 12 h, 40 oC. Isolated yield.
The reaction in Table 2 provides an alternative to the more classical assembly of aryl-substituted
pyrroles from aryl halides via cross coupling or C-H activation chemistry, where in this case the polycyclic
pyrrole core is generated at the same time as the (hetero)aryl-pyrrole bond. In considering this more
traditional use of palladium catalysis in C-C bond formation, we questioned if these functions might be
coupled to create a more modular synthesis of 3. It is well-established that terminal alkynes such as those
in 1c can undergo a Sonogashira coupling with the aryl iodides. We see no evidence for this
transformation above (Table 2), presumably due to the presence of carbon monoxide that diverts the aryl
iodide coupling towards reaction with the imine and Münchnone generation. As such, CO might be
employed to control selectivity between these two pathways, such that the absence of CO could allow an
initial Sonogashira coupling reaction on 1c. The subsequent addition of CO would in principle lead to a
second carbonylative cyclization, and provide a one pot, five component synthesis of diaryl-substituted
polycyclic pyrroles. From a mechanistic perspective, this would involve coupling three separate palladium
catalyzed reactions with both nucleophilic attack and spontaneous cycloaddition (Scheme 3).
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SCHEME 3. Mechanistic Postulate for a Tandem Catalytic, Palladium Catalyzed Coupling
After probing various reaction conditions, it was found that the same palladium catalyst could mediate
all of these steps. Thus, the Pd(PtBu3)2 / CuI catalyzed Sonogashira coupling of a terminal-alkyne tethered
imine, p-iodotoluene followed by the addition of CO to the same reaction vessel leads to the formation of
polysubstituted 5a in good yield (Table 3). While a number of phosphine ligands can be employed in the
initial Sonogashira coupling, this tandem catalytic reaction once again requires the use of PtBu3 in order to
facilitate the subsequent carbonylation chemistry, as well as the addition of a chloride source (Bu4NCl).
As with the pyrrole synthesis in Table 2, this tandem catalytic, multicomponent reaction can tolerate
substituents on the imine unit, and the use of N-benzyl protected imines (5b-h). The 2- and 3-aryl
positions in 5 can also be modulated. This includes, for example, the use of donor-substituted aryls, those
with electron withdrawing units, and even other heterocycles. Finally, we have found that this reaction
can also allow different aryl iodides to be incorporated into the core of 5. For this, the CO controlled
cyclization is useful, where an initial, high yielding non-CO based Sonogashira reaction can be followed
by the addition of a second aryl iodide in concert with CO for cyclization. This approach allows the
selective preparation of pyrroles 5g and 5h (Table 3). As far as we are aware, this represents one of the
few CO controlled tandem catalytic reactions, and allows the generation of 5 in an efficient fashion from
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five different reagents (two aryl iodides, two equivalents of carbon monoxide, and the alkyne-tethered
2
3
4
5
imine).
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TABLE 3. Tandem Catalytic, Five Component Polycyclic Pyrrole Synthesisa
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Imine
Ar-I
Product 5
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aa) 1 (0.5 mmol), ArI (5 mmol), Pd(PtBu3)2 (26 mg,
0.05 mmol), CuI (4.8 mg, 0.025 mmol), PtBu3 (20
mg, 0.1 mmol), NEtiPr2 (258 mg, 2 mmol), CH3CN,
5 h, r.t. b) Bu4NCl (278 mg, 1 mmol), CO (10 atm),
40°C, 16 h.
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Conclusion
In conclusion, we have described a new palladium catalyzed approach to assemble polycyclic
pyrroles from aryl iodides, CO, and alkyne-tethered imines. This reaction exploits the dicarbonylative
formation of Münchnone, which undergo spontaneous cycloaddition with tethered alkynes, and provides
access to these products from available reagents and minimal byproducts (HI and CO2). The
transformation can be diversified, and expanded to a one pot synthesis of polysubstituted variants of 3 via
a tandem Sonogashira/carbonylation reaction employing a single palladium catalyst. In principle, this
platform should be adaptable to access a range of alternative classes of heterocyclic products.
Experiments directed towards the latter are in progress.
Experimental Section
General procedures All experiments were conducted in an inert atmospheres glove box or using standard
Schlenk techniques, unless otherwise noted. Research grade carbon monoxide (99.99%) was used as
received. All reagents were purchased from commercial sources and used as received. CDCl3 and CD3CN
were distilled from CaH2 under nitrogen, vacuum transferred and stored over 4 Å molecular sieves.
Acetonitrile, dichlomethane and diethyl ether were dried with a solvent purification system.
Tetrabutylammonium chloride was dried in the glovebox by dissolving in dichloromethane, allowing it to
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stand overnight over activated 4 Å molecular sieves, then filtering and removing the solvent in vacuo.
Pd(PtBu3)2 was prepared as previously described.10b Nuclear magnetic resonance (NMR) characterization
was performed on 500 MHz spectrometers for proton, and 126 MHz for carbon. 1H and 13C NMR
chemical shifts were referenced to residual solvent. Mass spectra were recorded on a high-resolution
electrospray ionization quadrupole mass spectrometer.
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Typical Synthesis of Alkyne-Tethered Imines 1 In analogy to previous reports,12 a solution of
salicylaldehyde (366 mg, 3.0 mmol) and K2CO3 (1.0 g, 7.5 mmol) in DMF (15 ml) was prepared in a 100
mL round bottom flask equipped with a magnetic stir bar. The solution was allowed to stir for 20 minutes
at room temperature. To the solution was added 1-bromo-2-butyne (519 mg, 3.9 mmol). The reaction
mixture was allowed to stir overnight at room temperature. Water (20 mL) was then added and the
resulting mixture was extracted three times with diethyl ether (15 mL portions). The ether fractions were
combined and filtered through MgSO4. The solvent was removed in vacuo and the product was
recrystallized in ethanol to afford 2-(but-2-yn-1-yloxy)benzaldehyde (435 mg, 2.5 mmol) as a yellow
powder in 83% yield. To a solution of this 2-(but-2-yn-1-yloxy)benzaldehyde (435 mg, 2.5 mmol) in
dichloromethane (10 mL) was added Na2SO4 (1.0 g, 7.0 mmol) and ethylamine (2.0 M in THF) (1.6 mL,
3.25 mmol). The heterogeneous mixture was stirred at room temperature for 18 h. The reaction mixture
was filtered, and the solvent and excess amine were removed in vacuo to afford 1-(2-(but-2-yn-1-
yloxy)phenyl)-N-ethylmethanimine 1a (453 mg, 2.2 mmol) as a clear oil (88%). In the case of N-benzyl-
1-(2-(but-2-yn-1-yloxy)phenyl)methanimine 1b exactly 1.0 equivalent of benzylamine was added.
1-(2-(but-2-yn-1-yloxy)phenyl)-N-ethylmethanimine (1a)13 Isolated yield 88% (453 mg, 2.20 mmol).
1
Yellow oil. H NMR (500 MHz, CDCl3) δ 8.73 (s, 1H), 7.96 (dd, J = 7.6, 1.7 Hz, 1H), 7.40 – 7.30 (m,
1H), 7.00 (m, 2H), 4.71 (q, J = 2.3 Hz, 2H), 3.65 (qd, J = 7.3, 1.3 Hz, 2H), 1.85 (t, J = 2.3 Hz, 3H), 1.29
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(t, J = 7.3 Hz, 3H). 13C NMR (125 MHz, CDCl3) δ 156.9, 156.3, 131.4, 127.2, 125.4, 121.4, 112.7, 84.0,
73.9, 56.9, 56.0, 16.4, 3.6. HRMS: Calculated for C13H15NNaO (MNa+): 224.1046, found: 224.1052.
N-benzyl-1-(2-(but-2-yn-1-yloxy)phenyl)methanimine (1b) Isolated yield 90% (593 mg, 2.25 mmol).
Yellow oil. 1H NMR (500 MHz, CDCl3) δ 8.87 (d, J = 1.5 Hz, 1H), 8.04 (dd, J = 7.7, 1.8 Hz, 1H), 7.42 –
7.36 (m, 1H), 7.37 – 7.31 (m, 4H), 7.28 – 7.23 (m, 1H), 7.06 – 6.98 (m, 2H), 4.83 (d, J = 1.1 Hz, 2H),
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4.73 (q, J = 2.3 Hz, 2H), 1.87 (t, J = 2.3 Hz, 3H). C NMR (125 MHz, CDCl3) δ 157.9, 157.1, 139.7,
131.7, 128.4, 127.9, 127.5, 126.8, 125.2, 121.4, 112.8, 84.1, 73.8, 65.4, 57.0, 3.7. HRMS: Calculated for
C18H18NO (MH+): 264.1383, found: 264.1385.
N-ethyl-1-(2-(prop-2-yn-1-yloxy)phenyl)methanimine (1c) Isolated yield 95% (445 mg, 2.40 mmol).
Yellow oil. 1H NMR (500 MHz, CDCl3) δ 8.73 (s, 1H), 7.97 (dd, J = 8.1, 1.6 Hz, 1H), 7.42 – 7.33 (m,
1H), 7.03 (m, 2H), 4.76 (d, J = 2.4 Hz, 2H), 3.65 (qd, J = 7.3, 1.4 Hz, 2H), 2.53 (t, J = 2.4 Hz, 1H), 1.30
(t, J = 7.3 Hz, 3H). 13C NMR (125 MHz, CDCl3) δ 156.6, 156.1, 131.4, 127.4, 125.6, 121.8, 112.6, 78.3,
75.8, 56.3, 56.1, 16.3. HRMS: Calculated for C12H14NO (MH+) 188.1070, found: 188.1070.
N-benzyl-1-(2-(prop-2-yn-1-yloxy)phenyl)methanimine (1d) Isolated yield 90% (561 mg, 2.25 mmol).
Yellow oil. 1H NMR (500 MHz, CDCl3) δ 8.87 (d, J = 1.5 Hz, 1H), 8.06 (dd, J = 8.0, 1.8 Hz, 1H), 7.44 –
7.37 (m, 1H), 7.37 – 7.32 (m, 4H), 7.29 – 7.23 (m, 1H), 7.07 – 7.01 (m, 2H), 4.84 (d, J = 1.3 Hz, 2H),
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4.78 (d, J = 2.4 Hz, 2H), 2.54 (t, J = 2.4 Hz, 1H). C NMR (125 MHz, CDCl3) δ 157.8, 157.0, 139.8,
131.9, 128.6, 128.1, 127.8, 127.0, 125.6, 122.0, 112.9, 78.4, 76.0, 65.6, 56.5. HRMS. Calculated for
C17H16NO (MH+) 250.1226, found: 250.1225.
(E)-N-ethyl-1-(4-methoxy-2-(prop-2-yn-1-yloxy)phenyl)methanimine (1e) Isolated yield 85% (463 mg,
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2.10 mmol). Yellow powder. m.p. 57-58 °C. H NMR (500 MHz, CDCl3) δ 8.61 (s, 1H), 7.93 – 7.87 (m,
1H), 6.59 – 6.52 (m, 2H), 4.72 (d, J = 2.4 Hz, 2H), 3.82 (s, 3H), 3.60 (qd, J = 7.3, 1.4 Hz, 2H), 2.54 (t, J
= 2.4 Hz, 1H), 1.27 (t, J = 7.3 Hz, 3H). 13C NMR (125 MHz, CDCl3) δ 162.6, 157.9, 155.7, 128.6, 118.8,
106.6, 99.7, 78.3, 76.1, 56.4, 56.1, 55.5, 16.6. HRMS: Calculated for C13H16NO2 (MH+) 218.1176, found:
218.1178.
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Typical Synthesis of Polycyclic Pyrroles 3 In a glovebox, 1-(2-(but-2-yn-1-yloxy)phenyl)-N-
ethylmethanimine 1a (101 mg, 0.5 mmol), 4-iodotoluene (545 mg, 2.5 mmol), NEtiPr2 (97 mg, 0.75
mmol) in 3.3 ml acetonitrile were added to Pd(PtBu3)2 (13 mg, 0.025 mmol) and Bu4NCl (139 mg, 0.5
mmol) in a 4 mL glass vial equipped with a magnetic stir bar. The vial was capped with a pierced plastic
cap and placed inside a 50 mL Parr steel autoclave, which was sealed and taken out of the glovebox. The
reactor was charged with 10 atm CO using a Parr Multiwell Reactor 5000. The reactor was heated to 40oC
for 12 h in an oil bath. After allowing sufficient time to cool to room temperature, the CO atmosphere was
evacuated and the crude residue was purified by column chromatography on silica gel (eluent: n-
hexane/ethyl acetate 10:1) to afford 1-ethyl-3-methyl-2-(p-tolyl)-1,4-dihydrochromeno[4,3-b]pyrrole 3a as
a light yellow solid in 76% yield (115 mg, 0.38 mmol).
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1-ethyl-3-methyl-2-(p-tolyl)-1,4-dihydrochromeno[4,3-b]pyrrole (3a) Isolated yield 76% (115 mg, 0.38
mmol). Light yellow solid, mp 113-115 oC. 1H NMR (500 MHz, CDCl3) δ 7.42 (dd, J = 7.7, 1.6 Hz, 1H),
7.32 – 7.27 (m, 2H), 7.25 (d, J = 8.1 Hz, 2H), 7.08 (ddd, J = 8.7, 7.3, 1.6 Hz, 1H), 7.03 – 6.95 (m, 2H),
5.24 (s, 2H), 4.11 (q, J = 7.1 Hz, 2H), 2.45 (s, 3H), 1.94 (s, 3H), 1.26 (t, J = 7.1 Hz, 3H). 13C NMR (125
MHz, CDCl3) δ 153.2, 137.3, 134.0, 130.7, 129.3, 129.1, 126.1, 122.1, 121.6, 120.2, 119.9, 117.2, 116.2,
112.1, 64.9, 30.3, 21.3, 16.6, 9.3. HRMS: Calculated for C21H21NNaO (MNa+): 326.1515, found:
326.1516.
1-ethyl-2-(4-ethylphenyl)-3-methyl-1,4-dihydrochromeno[4,3-b]pyrrole (3b) Isolated yield 73% (111 mg,
0.36 mmol). White solid, 111-114 oC. 1H NMR (500 MHz, CDCl3) δ 7.44 (dd, J = 7.7, 1.6 Hz, 1H), 7.38 –
7.31 (m, 2H), 7.07 (ddd, J = 8.6, 7.3, 1.5 Hz, 1H), 7.02 – 6.93 (m, 4H), 5.97 (s, 1H), 5.22 (s, 2H), 4.20 (q,
J = 7.1 Hz, 2H), 3.87 (s, 3H), 1.30 (t, J = 7.1 Hz, 3H). 13C NMR (125 MHz, CDCl3) δ 159.2, 153.2, 137.0,
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130.9, 126.3, 125.6, 123.5, 121.6, 120.1, 120.0, 117.3, 116.8, 113.9, 104.6, 65.9, 55.3, 40.4, 16.6. HRMS
Calculated for C20H19NNaO2 (MNa+): 328.1308, found: 328.1309.
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1-ethyl-2-(4-methoxyphenyl)-3-phenyl-1,4-dihydrochromeno[4,3-b]pyrrole (3c) Isolated yield 95% (181
mg, 0.47 mmol). Light yellow solid, mp 138-140 oC. 1H NMR (500 MHz, CDCl3) δ 7.45 (dd, J = 7.8, 1.6
Hz, 1H), 7.24 – 7.16 (m, 4H), 7.15 – 7.07 (m, 2H), 7.04 – 6.96 (m, 4H), 6.94 – 6.87 (m, 2H), 5.28 (s, 2H),
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4.16 (q, J = 7.1 Hz, 2H), 3.84 (s, 3H), 1.30 (t, J = 7.1 Hz, 3H). C NMR (125 MHz, CDCl3) δ 159.2,
153.6, 134.8, 133.1, 132.6, 129.1, 128.0, 126.5, 125.3, 124.4, 122.7, 121.7, 120.5, 119.8, 119.2, 117.3,
115.1, 113.9, 65.0, 55.2, 40.0, 16.5. HRMS: Calculated for C26H24NO2 (MH+): 382.1802, found: 382.1795.
1-ethyl-3-phenyl-2-(p-tolyl)-1,4-dihydrochromeno[4,3-b]pyrrole (3d)14 Isolated yield 82% (150 mg, 0.41
mmol). Light yellow solid, 150-151 oC. 1H NMR (500 MHz, CDCl3) δ 7.46 (dd, J = 7.8, 1.5 Hz, 1H), 7.19
(d, J = 8.4 Hz, 6H), 7.14 – 7.08 (m, 2H), 7.05 – 6.96 (m, 4H), 5.28 (s, 2H), 4.16 (q, J = 7.1 Hz, 2H), 2.39
(s, 3H), 1.30 (t, J = 7.1 Hz, 3H).13C NMR (125 MHz, CDCl3) δ 153.6, 137.6, 134.8, 133.4, 131.3, 129.2,
129.18, 129.16, 128.0, 126.5, 125.4, 122.8, 121.7, 120.5, 119.8, 119.2, 117.3, 115.2, 65.0, 40.0, 21.3, 16.5.
HRMS: Calculated for C26H23NNaO (MNa+): 388.1672, found: 388.1667.
1-benzyl-3-methyl-2-(p-tolyl)-1,4-dihydrochromeno[4,3-b]pyrrole (3e) Isolated yield 60% (110 mg, 0.30
mmol). Light yellow solid, mp 150-153 oC. 1H NMR (500 MHz, CDCl3) δ 7.34 (t, J = 7.4 Hz, 2H), 7.30 –
7.23 (m, 1H), 7.15 (d, J = 7.7 Hz, 2H), 7.13 – 7.03 (m, 5H), 7.03 – 6.93 (m, 2H), 6.75 (td, J = 7.4, 1.9 Hz,
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1H), 5.31 (s, 2H), 5.26 (s, 2H), 2.38 (s, 3H), 2.05 (s, 3H). C NMR (125 MHz, CDCl3) δ 153.2, 139.1,
137.3, 134.7, 130.4, 129.0, 128.88, 128.83, 127.0, 126.2, 125.6, 123.2, 121.5, 120.5, 119.4, 117.0, 116.2,
112.3, 64.9, 49.2, 21.2, 9.6. HRMS: Calculated for C26H23NO (M+): 365.1774, found: 365.1764.
1-benzyl-2-(4-methoxyphenyl)-3-methyl-1,4-dihydrochromeno[4,3-b]pyrrole (3f) Isolated yield 83% (158
mg, 0.41 mmol). Light yellow solid, 133-138 oC. 1H NMR (500 MHz, CDCl3) δ 7.32 (td, J = 7.2, 6.3, 1.3
Hz, 2H), 7.28 – 7.21 (m, 1H), 7.14 – 7.07 (m, 2H), 7.07 – 7.00 (m, 3H), 7.00 – 6.93 (m, 2H), 6.88 – 6.81
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(m, 2H), 6.72 (ddd, J = 7.7, 6.9, 1.8 Hz, 1H), 5.28 (s, 2H), 5.22 (s, 2H), 3.80 (s, 3H), 2.00 (s, 3H). C
NMR (125 MHz, CDCl3) δ 159.0, 153.2, 139.1, 134.4, 131.7, 128.8, 127.0, 126.2, 125.6, 124.1, 123.0,
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121.5, 120.4, 119.5, 117.0, 116.0, 113.7, 112.2, 64.9, 55.2, 49.1, 9.6. HRMS: Calculated for C26H23NNaO2
(MNa+): 404.1621, found: 404.1614.
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1-ethyl-2-(4-methoxyphenyl)-3-methyl-1,4-dihydrochromeno[4,3-b]pyrrole (3g) Isolated yield 85% (136
mg, 0.42 mmol). Light yellow solid, mp 114-116 oC. 1H NMR (500 MHz, CDCl3) δ 7.39 (dd, J = 7.7, 1.5
Hz, 1H), 7.29 – 7.23 (m, 2H), 7.08 – 7.02 (m, 1H), 7.02 – 6.93 (m, 4H), 5.21 (s, 2H), 4.07 (q, J = 7.1 Hz,
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2H), 3.87 (s, 3H), 1.91 (s, 3H), 1.24 (t, J = 7.1 Hz, 3H). C NMR (125 MHz, CDCl3) δ 159.1, 153.1,
133.7, 132.1, 126.1, 124.6, 121.9, 121.6, 120.1, 119.9, 117.2, 116.1, 113.8, 112.0, 64.9, 55.2, 40.2, 16.6,
9.3. HRMS: Calculated for C21H22NO2 (MH+): 320.1645, found: 320.1638.
1-ethyl-2-(p-tolyl)-1,4-dihydrochromeno[4,3-b]pyrrole (3h) Isolated yield 61% (88 mg, 0.31 mmol).
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White solid, 122-125 C. 1H NMR (500 MHz, CDCl3) δ 7.46 (dd, J = 7.7, 1.6 Hz, 1H), 7.36 – 7.30 (m,
2H), 7.30 – 7.23 (m, 2H), 7.09 (ddd, J = 8.5, 7.2, 1.6 Hz, 1H), 7.04 – 6.96 (m, 2H), 6.02 (s, 1H), 5.24 (s,
2H), 4.24 (q, J = 7.1 Hz, 2H), 2.43 (s, 3H), 1.32 (t, J = 7.1 Hz, 3H). 13C NMR (125 MHz, CDCl3) δ 153.3,
137.4, 137.3, 130.3, 129.5, 129.2, 126.4, 123.7, 121.7, 120.1, 120.0, 117.3, 117.0, 104.8, 65.9, 40.5, 21.3,
16.6. HRMS: Calculated for C20H19NNaO (MNa+): 312.1359, found: 312.1364.
1-ethyl-7-methoxy-2-(p-tolyl)-1,4-dihydrochromeno[4,3-b]pyrrole (3i) Isolated yield 70% (112 mg, 0.35
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mmol). Light yellow solid. m.p. 103-105 °C. H NMR (500 MHz, CDCl3) δ 7.36 (d, J = 8.6 Hz, 1H), 7.33
– 7.29 (m, 2H), 7.24 (d, J = 7.9 Hz, 2H), 6.62 (d, J = 2.6 Hz, 1H), 6.56 (dd, J = 8.6, 2.7 Hz, 1H), 5.99 (s,
1H), 5.22 (s, 2H), 4.19 (q, J = 7.1 Hz, 2H), 3.81 (s, 3H), 2.42 (s, 3H), 1.30 (t, J = 7.1 Hz, 3H). 13C NMR
(125 MHz, CDCl3) δ 158.6, 154.8, 137.3, 136.4, 130.5, 129.5, 129.3, 124.1, 121.0, 114.9, 113.3, 107.4,
104.7, 103.5, 66.3, 55.4, 40.5, 21.4, 16.7. HRMS: Calculated for C21H22NO2 (MH+): 320.1645, found:
320.1644.
1-ethyl-2-(4-fluorophenyl)-3-methyl-1,4-dihydrochromeno[4,3-b]pyrrole (3j) Isolated yield 57% (88 mg,
0.28 mmol). Light yellow solid, mp 116-118 oC. 1H NMR (500 MHz, CDCl3) δ 7.40 (dd, J = 7.7, 1.6 Hz,
1H), 7.34 – 7.28 (m, 2H), 7.19 – 7.13 (m, 2H), 7.07 (ddd, J = 8.7, 7.3, 1.5 Hz, 1H), 7.02 – 6.94 (m, 2H),
5.21 (s, 2H), 4.07 (q, J = 7.1 Hz, 2H), 1.91 (s, 3H), 1.23 (t, J = 7.1 Hz, 3H). 13C NMR (125 MHz, CDCl3)
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δ 162.5 (d, J = 247.4 Hz), 153.4, 132.9, 132.7 (d, J = 8.1 Hz), 128.5 (d, J = 3.4 Hz), 126.5, 122.6, 121.8,
120.4, 119.9, 117.5, 116.4, 115.6 (d, J = 21.4 Hz), 112.6, 65.0, 40.4, 16.7, 9.5. HRMS: Calculated for
C20H19FNO (MH+): 308.1445, found: 308.1437.
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1-ethyl-2-(4-fluorophenyl)-3-phenyl-1,4-dihydrochromeno[4,3-b]pyrrole (3k) Isolated yield 60% (111
mg, 0.30 mmol). Light yellow solid, mp 180-183 oC. 1H NMR (500 MHz, CDCl3) δ 7.46 (dd, J = 7.7, 1.6
Hz, 1H), 7.31 – 7.24 (m, 2H), 7.24 – 7.17 (m, 2H), 7.16 – 6.99 (m, 6H), 6.99 – 6.92 (m, 2H), 5.27 (s, 2H),
4.15 (q, J = 7.2 Hz, 2H), 1.30 (t, J = 7.2 Hz, 3H). 13C NMR (125 MHz, CDCl3) δ 162.6 (d, J = 247.9 Hz),
153.9, 134.6, 133.4 (d, J = 8.1 Hz), 132.2, 129.3, 128.4 (d, J = 3.5 Hz), 128.3, 126.9, 125.8, 123.3, 121.9,
120.8, 119.8, 119.8, 117.6, 115.7 (d, J = 21.5 Hz), 115.5, 65.1, 40.2, 16.7. HRMS: Calculated for
C25H21FNO (MH+): 370.1602, found: 370.1599.
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2-(4-chlorophenyl)-1-ethyl-1,4-dihydrochromeno[4,3-b]pyrrole (3l) Isolated yield 66% (102 mg, 0.33
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mmol). White solid, mp 134-136 C. 1H NMR (500 MHz, CDCl3) δ 7.47 – 7.37 (m, 3H), 7.37 – 7.32 (m,
2H), 7.09 (ddd, J = 8.4, 7.2, 1.5 Hz, 1H), 7.02 – 6.94 (m, 2H), 6.02 (s, 1H), 5.20 (s, 2H), 4.21 (q, J = 7.2
Hz, 2H), 1.29 (t, J = 7.2 Hz, 3H). 13C NMR (125 MHz, CDCl3) δ 153.3, 135.9, 133.5, 131.6, 130.6, 128.7,
126.7, 124.5, 121.7, 120.3, 119.7, 117.4, 117.1, 105.3, 65.7, 40.6, 16.5. HRMS: Calculated for
C19H17ClNO (MH+) 310.0993, found: 310.0993.
1-ethyl-3-methyl-2-phenyl-1,4-dihydrochromeno[4,3-b]pyrrole (3m)13 Isolated yield 67% (97 mg, 0.33
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mmol). Light yellow solid, mp 98-101 C. 1H NMR (500 MHz, CDCl3) δ 7.47 (tt, J = 7.9, 1.4 Hz, 2H),
7.44 – 7.37 (m, 2H), 7.37 – 7.31 (m, 2H), 7.07 (ddd, J = 8.6, 7.3, 1.6 Hz, 1H), 7.03 – 6.93 (m, 2H), 5.23 (s,
2H), 4.11 (q, J = 7.1 Hz, 2H), 1.94 (s, 3H), 1.24 (t, J = 7.1 Hz, 3H). 13C NMR (125 MHz, CDCl3) δ 153.2,
134, 132.4, 130.8, 128.3, 127.5, 126.2, 122.4, 121.6, 120.3, 119.9, 117.2, 116.3, 112.3, 64.9, 40.3, 16.6,
9.4. HRMS: Calculated for C20H19NO (M+): 289.1461, found: 289.1452.
methyl 3-(1-ethyl-3-methyl-1,4-dihydrochromeno[4,3-b]pyrrol-2-yl)benzoate (3n) Isolated yield 73%
(127 mg, 0.36 mmol). Light yellow oil. 1H NMR (500 MHz, CDCl3) δ 8.09 – 8.01 (m, 2H), 7.56 – 7.51 (m,
2H), 7.41 (dd, J = 7.7, 1.6 Hz, 1H), 7.08 (ddd, J = 8.7, 7.2, 1.5 Hz, 1H), 6.98 (ddd, J = 14.7, 7.6, 1.4 Hz,
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2H), 5.20 (s, 2H), 4.09 (q, J = 7.1 Hz, 2H), 3.95 (s, 3H), 1.93 (s, 3H), 1.22 (t, J = 7.1 Hz, 3H). C NMR
(125 MHz, CDCl3) δ 167.0, 153.5, 135.3, 132.9, 132.0, 130.6, 128.8, 128.7, 126.6, 123.1, 121.8, 120.5,
119.9, 117.5, 116.6, 113.0, 64.9, 52.4, 40.6, 16.7, 9.5. HRMS: Calculated for C22H22NO3 (MH+):
348.1594, found: 348.1587.
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1-ethyl-2-(3-methoxyphenyl)-3-methyl-1,4-dihydrochromeno[4,3-b]pyrrole (3o) Isolated yield 60% (96
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mg, 0.30 mmol). Light yellow solid, mp 105-106 C. 1H NMR (500 MHz, CDCl3) δ 7.45 – 7.34 (m, 2H),
7.07 (ddd, J = 8.6, 7.3, 1.6 Hz, 1H), 7.02 – 6.91 (m, 4H), 6.89 (dd, J = 2.6, 1.5 Hz, 1H), 5.22 (s, 2H), 4.12
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(q, J = 7.1 Hz, 2H), 3.86 (s, 3H), 1.95 (s, 3H), 1.25 (t, J = 7.1 Hz, 3H). C NMR (125 MHz, CDCl3) δ
159.6, 153.4, 134.0, 133.8, 129.5, 126.4, 123.4, 122.6, 121.8, 120.4, 120.0, 117.4, 116.51, 116.48, 113.3,
112.4, 65.0, 55.4, 40.6, 16.8, 9.5. HRMS: Calculated for C21H21NNaO2 (MNa+): 342.1464, found:
342.1467.
2-(3,5-dimethylphenyl)-1-ethyl-3-methyl-1,4-dihydrochromeno[4,3-b]pyrrole (3p) Isolated yield 60% (95
mg, 0.30 mmol). Light yellow solid, mp 107-110 oC. 1H NMR (500 MHz, CDCl3) δ 7.40 (dd, J = 7.7, 1.6
Hz, 1H), 7.09 – 7.00 (m, 2H), 7.00 – 6.90 (m, 4H), 5.21 (s, 2H), 4.09 (q, J = 7.1 Hz, 2H), 2.38 (s, 6H),
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1.92 (s, 3H), 1.23 (t, J = 7.1 Hz, 3H). C NMR (125 MHz, CDCl3) δ 153.1, 137.7, 134.3, 132.2, 129.2,
128.6, 126.0, 122.1, 121.6, 120.2, 120.0, 117.2, 116.3, 112.0, 64.9, 40.3, 21.3, 16.6, 9.4. HRMS:
Calculated for C22H24NO (MH+): 318.1852, found: 318.1854.
1-benzyl-2-(3,5-dimethylphenyl)-3-methyl-1,4-dihydrochromeno[4,3-b]pyrrole (3q) Isolated yield 63%
(119 mg, 0.31 mmol). Light yellow solid, mp 119-121 oC. 1H NMR (500 MHz, CDCl3) δ 7.31 (dd, J = 8.1,
6.9 Hz, 2H), 7.24 (t, J = 7.5 Hz, 1H), 7.10 – 7.03 (m, 3H), 7.01 – 6.90 (m, 3H), 6.78 – 6.71 (m, 3H), 5.28
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(d, J = 1.1 Hz, 2H), 5.21 (s, 2H), 2.21 (s, 6H), 2.02 (d, J = 1.1 Hz, 3H). C NMR (125 MHz, CDCl3) δ
153.2, 139.3, 137.6, 135.0, 131.6, 129.1, 128.7, 128.3, 127.0, 126.2, 125.7, 124.2, 123.3, 121.5, 120.4,
119.5, 117.0, 116.1, 112.2, 64.9, 21.2, 9.6. HRMS: Calculated for C27H25NNaO (MNa+): 402.1828, found:
402.1831.
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1-ethyl-2-(thiophen-3-yl)-1,4-dihydrochromeno[4,3-b]pyrrole (3r) Isolated yield 78% (110 mg, 0.39
mmol). White solid, 85-90 oC. 1H NMR (500 MHz, CDCl3) δ 7.44 (dd, J = 7.7, 1.6 Hz, 1H), 7.40 (dd, J =
5.0, 3.0 Hz, 1H), 7.28 (dd, J = 3.0, 1.3 Hz, 1H), 7.18 (dd, J = 4.9, 1.3 Hz, 1H), 7.08 (ddd, J = 8.4, 7.2, 1.5
Hz, 1H), 7.02 – 6.95 (m, 2H), 6.06 (s, 1H), 5.21 (s, 2H), 4.26 (q, J = 7.2 Hz, 2H), 1.39 (t, J = 7.2 Hz, 3H).
13C NMR (125 MHz, CDCl3) δ 153.3, 133.4, 131.6, 128.7, 126.5, 125.6, 123.9, 122.6, 121.6, 120.1, 119.7,
117.3, 116.7, 104.9, 65.7, 40.5, 16.6. HRMS: Calculated for C17H15NNaOS (MNa+): 304.0767, found:
304.0771.
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1-ethyl-2-(1-tosyl-1H-indol-5-yl)-1,4-dihydrochromeno[4,3-b]pyrrole (3s) Isolated yield 70% (164 mg,
0.35 mmol). White solid, mp 160-163 oC. 1H NMR (500 MHz, CDCl3) δ 8.06 – 8.00 (m, 1H), 7.86 – 7.79
(m, 2H), 7.62 (d, J = 3.7 Hz, 1H), 7.55 (dd, J = 1.7, 0.7 Hz, 1H), 7.43 (dd, J = 7.7, 1.6 Hz, 1H), 7.35 (dd, J
= 8.5, 1.7 Hz, 1H), 7.27 (d, J = 8.6 Hz, 2H), 7.07 (ddd, J = 8.5, 7.2, 1.5 Hz, 1H), 7.01 – 6.94 (m, 2H), 6.69
(dd, J = 3.7, 0.8 Hz, 1H), 5.98 (s, 1H), 5.21 (s, 2H), 4.20 (q, J = 7.1 Hz, 2H), 2.37 (s, 3H), 1.26 (t, J = 7.1
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Hz, 3H). C NMR (125 MHz, CDCl3) δ 153.2, 145.1, 137.1, 135.3, 134.1, 130.8, 129.9, 128.3, 130.0,
129.9, 126.4, 126.3, 123.8, 122.3, 121.6, 120.1, 119.8, 117.3, 116.9, 113.3, 108.8, 105.0, 65.8, 40.5, 21.6,
16.5. HRMS: Calculated for C28H24N2NaO3S (MNa+): 491.1400, found: 491.1417.
Typical Synthesis of Polycyclic Pyrroles with Two Aryl Iodides (Table 3) In a glovebox, N-ethyl-1-(2-
(prop-2-yn-1-yloxy)phenyl)methanimine 1c (93 mg, 0.5 mmol), 4-iodotoluene (1090 mg, 5 mmol), and
NEtiPr2 (250 mg, 2 mmol) in 3.3 ml acetonitrile were added to Pd(PtBu3)2 (26 mg, 0.05 mmol), CuI (4.8
mg, 0.025 mmol), PtBu3 (20 mg, 0.1 mmol) and in a 4 mL glass vial equipped with a magnetic stir bar.
The mixture was allowed to stir at room temperature for 5 h. Bu4NCl (278 mg, 1.0 mmol) was then added,
and the vial was capped with a pierced plastic cap and placed inside a 50 mL Parr steel autoclave, which
was sealed and taken out of the glovebox. The reactor was charged with 10 atm CO using a Parr
Multiwell Reactor 5000. The reactor was heated to 40 oC for 12 h. After allowing sufficient time to cool
to room temperature, the CO atmosphere was evacuated and the crude residue was purified by column
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chromatography on silica gel (eluent: n-hexane/ethylacetate 10:1) to afford 1-ethyl-2,3-di-p-tolyl-1,4-
dihydrochromeno[4,3-b]pyrrole 5a as a light yellow solid in 72% yield (137 mg, 0.36 mmol).
Pyrrole 5g was synthesized in a similar fashion with the use of 4-iodotoluene (120 mg, 0.55 mmol)
in the first step (6 h), followed by the addition of Bu4NCl (278 mg, 1.0 mmol) and 4-iodoanisole (585 mg,
2.5 mmol) for cyclization. For 5h, the procedure was modified as follows: imine 1e (109 mg, 0.5 mmol),
1-chloro-4-iodobenzene (119 mg, 0.5 mmol), DABCO (168 mg, 1.5 mmol), and PtBu3 (20 mg, 0.1 mmol)
were dissolved in 9 mL of MeCN and added to a 20 mL vial containing CuI (2.4 mg, 0.0125 mmol) and
Pd(PtBu3)2 (26 mg, 0.05 mmol). The vial was equipped with a stir bar and the mixture was allowed to stir
at room temperature for 48 h. Bu4NCl (278 mg, 1.0 mmol) and 3-iodothiophene (525 mg, 2.5 mmol) were
added to the solution together with 3 mL MeCN. The system was sealed, taken out of the glovebox, and
charged with 10 atm CO. Similar isolation to that above afforded 3-(4-chlorophenyl)-1-ethyl-7-methoxy-
2-(thiophen-3-yl)-1,4-dihydrochromeno[4,3-b]pyrrole 5h as a light yellow solid (112 mg, 0.26 mmol) in
53% yield.
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1-ethyl-2,3-di-p-tolyl-1,4-dihydrochromeno[4,3-b]pyrrole (5a) Isolated yield 72% (137 mg, 0.36 mmol).
Light yellow solid, mp 125-130 oC. 1H NMR (500 MHz, CD3CN) δ 7.54 (dd, J = 7.8, 1.5 Hz, 1H), 7.25 –
7.21 (m, 2H), 7.21 – 7.16 (m, 2H), 7.11 (td, J = 7.7, 1.6 Hz, 1H), 7.05 – 6.99 (m, 3H), 6.97 (dd, J = 8.0,
1.4 Hz, 1H), 6.91 – 6.85 (m, 2H), 5.18 (s, 2H), 4.11 (q, J = 7.2 Hz, 2H), 2.37 (s, 3H), 2.26 (s, 3H), 1.20 (t,
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J = 7.2 Hz, 3H). C NMR (125 MHz, CDCl3) δ 154.4, 139.0, 136.3, 134.2, 132.7, 132.4, 130.2, 130.02,
130.00, 129.7, 127.6, 123.2, 122.9, 121.9, 120.5, 119.9, 118.0, 116.1, 65.6, 40.9, 21.3, 21.0, 16.7. HRMS:
Calculated for C27H25NNaO (MNa+): 402.1828, found: 402.1824.
1-ethyl-2,3-diphenyl-1,4-dihydrochromeno[4,3-b]pyrrole (5b) Isolated yield 62% (109 mg, 0.31 mmol).
o
Light yellow solid, mp 96-100 C. 1H NMR (500 MHz, CDCl3) δ 7.46 (dd, J = 7.7, 1.6 Hz, 1H), 7.39 –
7.34 (m, 3H), 7.32 – 7.27 (m, 2H), 7.22 – 7.16 (m, 2H), 7.11 (ddt, J = 8.5, 7.3, 1.5 Hz, 2H), 7.05 – 6.99
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(m, 2H), 6.99 – 6.94 (m, 2H), 5.28 (s, 2H), 4.18 (q, J = 7.1 Hz, 2H), 1.31 (t, J = 7.2 Hz, 3H). C NMR
(125 MHz, CDCl3) δ 153.6, 134.6, 132.2, 131.5, 129.1, 128.4, 128.0, 127.8, 126.6, 126.2, 125.4, 122.9,
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121.7, 120.5, 119.7, 119.3, 117.4, 115.3, 65.0, 40.1, 16.5. HRMS: Calculated for C25H21NNaO (MNa+):
374.1515, found: 374.1521.
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1-ethyl-2,3-bis(4-fluorophenyl)-1,4-dihydrochromeno[4,3-b]pyrrole (5c) Isolated yield 63% (122 mg,
0.31 mmol). Light yellow solid, mp 170-173 oC. 1H NMR (500 MHz, CDCl3) δ 7.45 (dd, J = 7.8, 1.5 Hz,
1H), 7.28 – 7.22 (m, 2H), 7.14 – 7.05 (m, 3H), 7.05 – 6.98 (m, 2H), 6.93 – 6.88 (m, 4H), 5.23 (s, 2H), 4.15
(q, J = 7.1 Hz, 2H), 1.30 (t, J = 7.2 Hz, 3H). 13C NMR (125 MHz, CDCl3) δ 162.7 (d, J = 248.4 Hz), 161.3
(d, J = 245.1 Hz), 153.8, 133.3 (d, J = 8.2 Hz), 132.2, 130.7 (d, J = 7.8 Hz), 130.6 (d, J = 3.2 Hz), 128.2
(d, J = 3.4 Hz), 127.0, 123.3, 122.0, 120.8, 119.7, 118.9, 117.6, 115.8 (d, J = 21.5 Hz), 115.3, 115.3 (d, J =
21.2 Hz), 65.0, 40.3, 16.7. HRMS Calculated for C25H20F2NO (MH+): 388.1507, found: 388.1508.
1-benzyl-2,3-bis(4-fluorophenyl)-1,4-dihydrochromeno[4,3-b]pyrrole (5d) Isolated yield 65% (146 mg,
0.32 mmol). Light yellow solid, 150-155 oC. 1H NMR (500 MHz, CDCl3) δ 7.35 (t, J = 7.4 Hz, 2H), 7.13 –
7.01 (m, 9H), 6.99 – 6.91 (m, 5H), 6.80 (td, J = 7.7, 1.3 Hz, 1H), 5.33 (s, 2H), 5.32 (s, 2H). 13C NMR (125
MHz, CDCl3) δ 162.6 (d, J = 248.4 Hz), 161.4 (d, J = 245.2 Hz), 153.8, 138.4, 133.1 (d, J = 8.0 Hz), 130.9
(d, J = 7.8 Hz), 130.6 (d, J = 3.2 Hz), 129.1, 127.7 (d, J = 3.3 Hz), 127.5, 127.1, 125.7, 124.5, 121.9,
121.0, 119.2, 119.1, 117.4, 115.7 (d, J = 21.5 Hz), 115.4 (d, J = 21.4 Hz), 115.3, 113.2, 65.0, 49.2. HRMS:
Calculated for C30H21F2NNaO (MNa+): 472.1483, found: 472.1494.
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1-benzyl-2,3-di-p-tolyl-1,4-dihydrochromeno[4,3-b]pyrrole (5e) Isolated yield 70% (154 mg, 0.35 mmol).
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Light yellow solid, 156-160 oC. H NMR (500 MHz, CDCl3) δ 7.34 (t, J = 7.5 Hz, 2H), 7.27 (m, 2H), 7.13
– 7.03 (m, 9H), 7.00 (m, 3H), 6.77 (m, 1H), 5.36 (s, 2H), 5.35 (s, 2H), 2.33 (s, 6H).13C NMR (125 MHz,
CDCl3) δ 135.5, 138.6, 137.5, 135.1, 134.2, 131.8, 131.1, 129.1, 129.0, 128.9, 128.8, 128.7, 127.1, 126.5,
125.6, 123.9, 121.5, 120.7, 119.4, 119.3, 117.1, 115.2, 65.1, 48.9, 21.2, 21.1. HRMS: Calculated for
C32H27NNaO (MNa+): 464.1985, found: 464.1993.
1-benzyl-2,3-diphenyl-1,4-dihydrochromeno[4,3-b]pyrrole (5f) Isolated yield 65% (134 mg, 0.32 mmol).
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Light yellow solid, m.p. 150-153 oC. H NMR (500 MHz, CDCl3) δ 7.34 (t, J = 7.5 Hz, 2H), 7.25 (m, 6H),
7.20 – 7.14 (m, 4H), 7.13 – 7.04 (m, 5H), 7.04 – 6.99 (m, 1H), 6.79 (td, J = 7.7, 1.5 Hz, 1H), 5.37 (s, 4H).
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13C NMR (125 MHz, CDCl3) δ 153.6, 138.4, 134.7, 134.3, 131.7, 131.2, 129.3, 128.8, 128.3, 128.1, 127.8,
127.1, 126.7, 125.7, 125.6, 124.2, 121.6, 120.8, 119.6, 119.2, 117.1, 115.3, 65.0, 49.0. HRMS: Calculated
for C30H23NNaO (MNa+): 436.1672, found: 436.1682.
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(138 mg, 0.35 mmol). Light yellow solid, m.p. 133-136 °C. H NMR (500 MHz, CDCl3) δ 7.45 (dd, J =
7.7, 1.3 Hz, 1H), 7.25 – 7.19 (m, 2H), 7.12 – 7.07 (m, 1H), 7.04 – 6.97 (m, 4H), 6.94 – 6.90 (m, 2H), 6.88
(d, J = 8.1 Hz, 2H), 5.28 (s, 2H), 4.15 (q, J = 7.1 Hz, 2H), 3.84 (s, 3H), 2.29 (s, 3H), 1.30 (t, J = 7.1 Hz,
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3H). C NMR (125 MHz, CDCl3) δ 159.4, 153.8, 135.0, 133.1, 132.8, 131.9, 129.1, 129.0, 126.6, 124.7,
122.7, 121.8, 120.6, 120.0, 119.3, 117.5, 115.3, 114.0, 65.2, 55.4, 40.1, 21.2, 16.7. HRMS: Calculated for
C27H26NO2 (MH+): 396.1958, found: 396.1961.
3-(4-chlorophenyl)-1-ethyl-7-methoxy-2-(thiophen-3-yl)-1,4-dihydrochromeno[4,3-b]pyrrole (5h) Isolated
yield 53% (112 mg, 0.26 mmol). Light orange solid. m.p. 132-134 °C. 1H NMR (500 MHz, CDCl3) δ 7.40
– 7.33 (m, 2H), 7.22 – 7.14 (m, 3H), 7.01 – 6.97 (m, 1H), 6.91 (d, J = 8.4 Hz, 2H), 6.64 (d, J = 2.6 Hz,
1H), 6.59 (dd, J = 8.6, 2.6 Hz, 1H), 5.23 (s, 2H), 4.16 (q, J = 7.1 Hz, 2H), 3.82 (s, 3H), 1.34 (t, J = 7.2 Hz,
3H). 13C NMR (125 MHz, CDCl3) δ 159.0, 155.3, 133.5, 132.0, 131.5, 130.3, 130.0, 128.5, 126.9, 126.1,
125.9, 123.8, 121.5, 118.9, 113.1, 112.8, 107.8, 103.5, 65.2, 55.5, 40.3, 16.7. HRMS: Calculated for
C24H20NClSO2 (M+): 421.0898, found: 421.0890.
ACKNOWLEDGMENT We thank NSERC, CFI, and the FQRNT supported Centre for Green
Chemistry and Catalysis for their financial support of this research.
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Supporting Information Available: H and C NMR spectra for compounds 1-5. This material is
available free of charge via the Internet at http://pubs.acs.org.
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52
53
54
55
56
57
58
59
60
ACS Paragon Plus Environment