Catalytic asymmetric arylation of N-substituted 2-pyrrolines with aryl triflates

Article abstract of DOI:10.1016/0022-328X(92)83236-B

Catalytic asymmetric arylation of 1-(alkoxycarbonyl)-2-pyrrolines (4) with aryl triflates (1) in benzene in the presence of a base and a palladium catalyst, prepared in situ by mixing Pd(OAc)2 and (R)-BINAP, gives optically active (R)-1-(alkoxycarbonyl)5-aryl-2-pyrrolines (5) of up to 83percent ee. together with the regioisomers 1-(alkoxycarbonyl)-5-aryl-3-pyrrolines (6).