Tandem approaches for the synthesis of functionalized pyrrolidones: Efficient routes toward allokainic acid and kainic acid

Article abstract of DOI:10.1016/j.tetlet.2012.11.007

Tandem approaches for the synthesis of pyrrolidone precursor of allokainic acid and kainic acid are described. The synthesis of pyrrolidone intermediate of allokainic acid is achieved by tandem Wittig-Michael reaction and tandem amidation-Michael reaction