Stereoselective addition of 2-aminothiophenol to α-alkoxycinnamic acid derivatives - Alternative synthesis of (±)-diltiazem

DOI: 10.1016/S0040-4020(01)88031-5

Source and publish data:

Tetrahedron p. 8119 - 8128 (1993)

Update date:2022-07-30

Topics:

Authors:

Miyata, Okiko

Shinada, Tetsuro

Naito, Takeaki

Ninomiya, Ichiya

Date, Tadamasa

Okamura, Kimio

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Article abstract of DOI:10.1016/S0040-4020(01)88031-5

A stereocontrolled synthesis of (±)-diltiazem by applying nucleophilic addition of 2-aminothiophenol to α-alkoxycinnamic acid derivatives is described.

Full text of DOI:10.1016/S0040-4020(01)88031-5

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Product name:Benzenepropanoic acid, b-hydroxy-a-[(2-methoxyethoxy)methoxy]-, ethyl ester

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