An aqueous, catalyst-free and three-component synthesis of 6-amino-3-(trifluoromethyl)-1,4-dihydro-1-phenyl-4-arylpyrano[2,3-c] pyrazole-5-carbonitriles

Article abstract of DOI:10.1007/s11164-013-1058-7

A concise synthesis of 6-amino-4-aryl-3-(trifluoromethyl)-1,4-dihydro-1- phenylpyrano[2,3-c]pyrazole-5-carbonitriles was performed effectively in aqueous media without catalyst by the reaction of aryl aldehydes, malononitrile, and 1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one. This method has the advantages of mild condition, avoidance of the use of catalysts, high yields, and environmentally benign procedure.