SYNTHESIS OF NOVEL DNA PHOTOCLEAVING AGENTS WITH POTENT DNA CLEAVING ACTIVITY

Article abstract of DOI:10.1016/S0040-4039(00)79060-5

Novel DNA photocleavers consisting of the photoactive p-nitrobenzoyl group, an intercalator an a DNA groove binder were designed and synthesized.The importance of the groove binding region to the DNA breakage ability was studied.Key Words: intercalation;