53. Synthesis of Dipeptides via Addition of N-(Nitroacetyl)amino-Acid Derivatives to Michael Acceptors: Scope, Stereoselectivity, and Absolute Configuration

Article abstract of DOI:10.1002/hlca.19920750306

Michael addition of N-nitroacetyl derivatives 1 of proline esters using KF under phase-transfer catalysis resulted in the formation of adducts 3-9 with chemical yields ranging from 40-90percent (Scheme).Stereoselectivity of up to 51 percent was obtained o