Russian Journal of Bioorganic Chemistry p. 328 - 334 (2012)
Update date:2022-08-05
Topics:
Lee, Chan Woo
Park, Nok Hyun
Kim, Jin Woong
Um, Byung Hun
Shpatov
Shults
Sorokina
Popov
Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their syn-thetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succi-nates. Down-regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid). Pleiades Publishing, Ltd., 2012.
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