Inhibition of DD -peptidases by a specific trifluoroketone: Crystal structure of a complex with the actinomadura R39 DD -peptidase

Article abstract of DOI:10.1021/bi400048s

Inhibitors of bacterial dd-peptidases represent potential antibiotics. In the search for alternatives to β-lactams, we have investigated a series of compounds designed to generate transition state analogue structures upon reaction with dd-peptidases. The