Synthesis and pharmacological evaluation of enantiomerically pure 4-deoxy- 4-fluoromuscarines

Article abstract of DOI:10.1021/jm00095a003

Four isomers of [(4-fluoro-5-methyl-tetrahydrofuran-2- yl)methyl]trimethylammonium iodide (4-deoxy-4-fluoromuscarines) were prepared in enantiomerically and diastereomerically pure form from (S)-(-)-methyl 4- methylphenyl sulfoxide, ethyl fluoroacetate, a