3'-Azido-3', 5'-dideoxythymidine-5'-methylphosphonic Acid Diphosphate: Synthesis and HIV-1 Reverse Transcriptase Inhibition

DOI: 10.1021/jm00095a014

Source and publish data:

Journal of Medicinal Chemistry p. 3192 - 3196 (1992)

Update date:2022-07-30

Topics:

Authors:

Freeman, G. A.

Rideout, J. L.

Miller, W. H.

Reardon, J. E.

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Article abstract of DOI:10.1021/jm00095a014

3'-Azido-3'-deoxythymidine-5'-phosphonate was synthesized by five-step reaction sequence.The 5'-phosphonate was inactive against HIV-1 in MT4 cells.The absence of activity against HIV-1- was at least partially explained by demonstrating that the K_{m
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Full text of DOI:10.1021/jm00095a014

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