3'-Azido-3', 5'-dideoxythymidine-5'-methylphosphonic Acid Diphosphate: Synthesis and HIV-1 Reverse Transcriptase Inhibition

DOI: 10.1021/jm00095a014

Source and publish data:

Journal of Medicinal Chemistry p. 3192 - 3196 (1992)

Update date:2022-07-30

Topics:

Authors:

Freeman, G. A.

Rideout, J. L.

Miller, W. H.

Reardon, J. E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00095a014

3'-Azido-3'-deoxythymidine-5'-phosphonate was synthesized by five-step reaction sequence.The 5'-phosphonate was inactive against HIV-1 in MT4 cells.The absence of activity against HIV-1- was at least partially explained by demonstrating that the K_{m
View More}

Full text of DOI:10.1021/jm00095a014

Products guided by the article

Product name:(E,2R,4S,5R)-1-<4-azidotetrahydro-5-<2-(di-O-phenylphosphono)vinyl>-2-furyl>thymine

Cas No:142802-31-1

R&D Labs maybe for 142802-31-1

X.T.Y Environ-Tech Co.,Ltd

Contact:+86-310-7092106

Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Shanggao Ruiya Fine Chemicals Co., Ltd

Contact:+86-795-2592103

Address:Xingguang Nanlu,Shanggao County Industry Park
Tractus Company Limited

Contact:+852-8198 2399

Address:9E, Leapont Industrial Building, 18-28 Wo Liu Hang Road, Shatin, New Territories, Hong Kong
Suzhou Ryan Pharmachem Technology Co.,Ltd

Contact:+86-0512-68780025

Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China
Wuhan Shangrisyn chemicals Technology Co.,Ltd(expird)

Contact:+86-027-84466317 __ +86-15387123698

Address:wuhan - china

Relevant to this article

Solution-phase parallel synthesis of a multisubstituted cyclic imidate library

Doi:10.1021/co3001605
(2013)
Ni(II)-catalyzed oxidative coupling between C(sp²)-H in benzamides and C(sp³)-H in toluene derivatives

Doi:10.1021/ja5095342
(2014)
1,3-Dipolar cycloadditions of ruthenium(II) azido complexes with alkynes and nitriles

Doi:10.1021/ic302264t
(2013)
An improved fluorogenic substrate for the detection of alkaline phosphatase activity

Doi:10.1016/j.bmcl.2013.02.063
(2013)
Configurational stability of optically active dichloromethyl p-tolyl sulfoxide and its anionic species: Experimental and theoretical study

Doi:10.1002/hc.21074
(2013)
Synthesis, preliminary structure-activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives as potential anti-inflammatory agents

Doi:10.1016/j.bmcl.2013.02.059
(2013)

Article Doi