Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones

Article abstract of DOI:10.1021/jm00096a001

Synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5- methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-HT₃ antagonists are described. The key pharmacophoric elements were defined as a basic nitrogen, a linking group capable o