Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones

DOI: 10.1021/jm00096a001

Source and publish data:

Journal of Medicinal Chemistry p. 3307 - 3319 (1992)

Update date:2022-08-05

Topics:

Authors:

Matsui Matsui

Sugiura Sugiura

Nakai Nakai

Iguchi Iguchi

Shigeoka

Takada Takada

Odagaki Odagaki

Nagao Nagao

Ushio Ushio

Ohmoto Ohmoto

Iwamura Iwamura

Yamazaki

Arai Arai

Kawamura

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Article abstract of DOI:10.1021/jm00096a001

Synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5- methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-HT₃ antagonists are described. The key pharmacophoric elements were defined as a basic nitrogen, a linking group capable o

Full text of DOI:10.1021/jm00096a001

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