Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones

DOI: 10.1021/jm00096a001

Source and publish data:

Journal of Medicinal Chemistry p. 3307 - 3319 (1992)

Update date:2022-08-05

Topics:

Authors:

Matsui Matsui

Sugiura Sugiura

Nakai Nakai

Iguchi Iguchi

Shigeoka

Takada Takada

Odagaki Odagaki

Nagao Nagao

Ushio Ushio

Ohmoto Ohmoto

Iwamura Iwamura

Yamazaki

Arai Arai

Kawamura

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00096a001

Synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5- methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-HT₃ antagonists are described. The key pharmacophoric elements were defined as a basic nitrogen, a linking group capable o

Full text of DOI:10.1021/jm00096a001

Products guided by the article

Product name:Benzo[c]-2,6-naphthyridin-1(2H)-one, 2-[[5-methyl-1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]-

Cas No:143075-60-9

R&D Labs maybe for 143075-60-9

shanghai payne pharm co.,ltd.

Contact:+86-021-58123769

Address:No.780 of Cailun Road,Zhangjiang Hi-tech Park,Pudong,Shanghai
ANHUI CHEM-BRIGHT BIOENGINEERING CO.,LTD

Contact:86-561-4080321

Address:No.8 Lieshan Industrial Zone of Huaibei
xuri chemicals co., ltd

Contact:86-516-66656369

Address:The west road of Huaihai, Xuzhou, China
Yicheng Goto Pharmaceuticals Co.,Ltd.

Contact:+86 710 3423122

Address:5th Floor,East Gate of Building #2,Servo-Industrial Park,1st Qilin Road,Xiangyang,Hubei,China
SINO Industries Company Limited(expird)

Contact:86-29-85369724

Address:No.111, Jiefang Road, Xi’an, China

Relevant to this article

An efficient approach for the construction of benzazepine and benzoxepine derivatives

Doi:10.1002/asia.201200636
(2012)
A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis

Doi:10.1039/c3ob40407b
(2013)
L-shaped benzimidazole fluorophores: Synthesis, characterization and optical response to bases, acids and anions

Doi:10.1039/c2cc37120k
(2013)
Cu-catalyzed synthesis of diaryl thioethers and S -cycles by reaction of aryl iodides with carbon disulfide in the presence of DBU

Doi:10.1021/jo400709s
(2013)
Highly reactive (<1 min) ratiometric probe for selective 'naked-eye' detection of cyanide in aqueous media

Doi:10.1016/j.tetlet.2012.12.092
(2013)
Total synthesis of (±)-δ-rubromycin

Doi:10.1021/ol400864f
(2013)

Article Doi