Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones

DOI: 10.1021/jm00096a001

Source and publish data:

Journal of Medicinal Chemistry p. 3307 - 3319 (1992)

Update date:2022-08-05

Topics:

Authors:

Matsui Matsui

Sugiura Sugiura

Nakai Nakai

Iguchi Iguchi

Shigeoka

Takada Takada

Odagaki Odagaki

Nagao Nagao

Ushio Ushio

Ohmoto Ohmoto

Iwamura Iwamura

Yamazaki

Arai Arai

Kawamura

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00096a001

Synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5- methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-HT₃ antagonists are described. The key pharmacophoric elements were defined as a basic nitrogen, a linking group capable o

Full text of DOI:10.1021/jm00096a001

Products guided by the article

Product name:Benzo[c]-2,6-naphthyridin-1(2H)-one, 2-[[5-methyl-1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]-

Cas No:143075-60-9

R&D Labs maybe for 143075-60-9

Tianjin Emulsion Science&Technology Development Co.,Ltd

Contact:13901380442

Address:Vake Garden New Town New Yi Bai Road Beichen District Tianjin,China
Jurong Huaheng Natural Biological Products Factory

website:http://www.risebiochem.com

Contact:+86-13921007726

Address:Chuncheng town,Jurong city,Jiangsu province,China
ANHUI CHEM-BRIGHT BIOENGINEERING CO.,LTD

Contact:86-561-4080321

Address:No.8 Lieshan Industrial Zone of Huaibei
Shanghai Bocimed Pharmaceutical Co., Ltd.

website:http://www.bocimed.com

Contact:+86-21-68861632

Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
Simagchem Corporation

website:http://www.simagchem.com

Contact:+86-592-2680277

Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China

Relevant to this article

An efficient approach for the construction of benzazepine and benzoxepine derivatives

Doi:10.1002/asia.201200636
(2012)
A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis

Doi:10.1039/c3ob40407b
(2013)
L-shaped benzimidazole fluorophores: Synthesis, characterization and optical response to bases, acids and anions

Doi:10.1039/c2cc37120k
(2013)
Cu-catalyzed synthesis of diaryl thioethers and S -cycles by reaction of aryl iodides with carbon disulfide in the presence of DBU

Doi:10.1021/jo400709s
(2013)
Highly reactive (<1 min) ratiometric probe for selective 'naked-eye' detection of cyanide in aqueous media

Doi:10.1016/j.tetlet.2012.12.092
(2013)
Total synthesis of (±)-δ-rubromycin

Doi:10.1021/ol400864f
(2013)

Article Doi