Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones

DOI: 10.1021/jm00096a001

Source and publish data:

Journal of Medicinal Chemistry p. 3307 - 3319 (1992)

Update date:2022-08-05

Topics:

Authors:

Matsui Matsui

Sugiura Sugiura

Nakai Nakai

Iguchi Iguchi

Shigeoka

Takada Takada

Odagaki Odagaki

Nagao Nagao

Ushio Ushio

Ohmoto Ohmoto

Iwamura Iwamura

Yamazaki

Arai Arai

Kawamura

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00096a001

Synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5- methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-HT₃ antagonists are described. The key pharmacophoric elements were defined as a basic nitrogen, a linking group capable o

Full text of DOI:10.1021/jm00096a001

Products guided by the article

Product name:Benzo[c]-2,6-naphthyridin-1(2H)-one, 2-[[5-methyl-1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]-

Cas No:143075-60-9

R&D Labs maybe for 143075-60-9

Yangzhou Zhongbao Pharmaceutical Co.,Ltd

Contact:+86-514-88290838

Address:Jiangsu Baoying county economic develpment zone in baoying avenue91
Zhejiang Haizhou Pharmaceutical Co., Ltd.

website:https://www.haizhoupharma.com/

Contact:+86-576-88221016

Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
Shanghai Forever Synthesis Co.,Ltd.

Contact:021-61124658

Address:Zhoukang Road,Pudong New District,Shanghai,China
LINAN HAIHUA CHEMICAL CO LTD

Contact:86-571-61063068

Address:LINAN
Hubei Vanz Pharm Co.,Ltd

website:http://www.vanzpharm.com/en/index.html

Contact:86-27-84492310

Address:FANHU INDUSTRY PARK

Relevant to this article

An efficient approach for the construction of benzazepine and benzoxepine derivatives

Doi:10.1002/asia.201200636
(2012)
A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis

Doi:10.1039/c3ob40407b
(2013)
L-shaped benzimidazole fluorophores: Synthesis, characterization and optical response to bases, acids and anions

Doi:10.1039/c2cc37120k
(2013)
Cu-catalyzed synthesis of diaryl thioethers and S -cycles by reaction of aryl iodides with carbon disulfide in the presence of DBU

Doi:10.1021/jo400709s
(2013)
Highly reactive (<1 min) ratiometric probe for selective 'naked-eye' detection of cyanide in aqueous media

Doi:10.1016/j.tetlet.2012.12.092
(2013)
Total synthesis of (±)-δ-rubromycin

Doi:10.1021/ol400864f
(2013)

Article Doi