Angewandte Chemie - International Edition p. 3009 - 3014 (2013)
Update date:2022-08-05
Topics:
Gersch, Malte
Gut, Felix
Korotkov, Vadim S.
Lehmann, Johannes
B?ttcher, Thomas
Rusch, Marion
Hedberg, Christian
Waldmann, Herbert
Klebe, Gerhard
Sieber, Stephan A.
Catch me if you can: The ClpP protease mediates protein homeostasis and can be efficiently inhibited by β-lactones. A combination of molecular docking, mutagenesis, activity-based protein profiling, and kinetics studies now reveals the mechanism of ClpP inhibition. A hydrophobic pocket next to the active site allows binding of long aliphatic and aromatic residues. The preferred stereoisomer binds into the oxyanion hole. Copyright
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(2013)
