Acremolin from acremonium strictum is N 2,3-etheno-2′- isopropyl-1-methylguanine, not a 1 H -azirine. Synthesis and structural revision

DOI: 10.1021/ol400752s

Source and publish data:

Organic Letters p. 2370 - 2373 (2013)

Update date:2022-08-05

Topics:

Authors:

Januar, Lawrence A.

Molinski, Tadeusz F.

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Article abstract of DOI:10.1021/ol400752s

The first synthesis of the heterocyclic marine natural product, acremolin, is reported along with the revision of the structure from a 1H-azirine to a substituted N²,3-ethenoguanine (5-methyl-7-isopropyl-4,5- dihydroimidazo[2,1-b]purine). Additional properties of acremolin are also described including its ¹H-¹⁵N-HMBC and fluorescence spectra.

Full text of DOI:10.1021/ol400752s

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