Synthesis and Evaluation of 5-Amino-5,6,7,8-tetrahydroquinolinones as Potential Agents for the Treatment of Alzheimer's Disease

DOI: 10.1021/jm00018a025

Source and publish data:

Journal of Medicinal Chemistry p. 3645 - 3651 (1995)

Update date:2022-07-31

Topics:

Authors:

Fink, David M.

Bores, Gina M.

Effland, Richard C.

Huger, Francis P.

Kurys, Barbara E.

et al. et al.

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Article abstract of DOI:10.1021/jm00018a025

A series of 5-amino-5,6,7,8-tetrahydroquinolinones was designed and synthesized as acetylcholinesterase inhibitors.The compounds are related to hyperzine A, a naturally occurring cholinesterase inhibitor.They inhibit acetylcholinesterase in vitro, and man

Full text of DOI:10.1021/jm00018a025

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