Synthesis and Evaluation of 5-Amino-5,6,7,8-tetrahydroquinolinones as Potential Agents for the Treatment of Alzheimer's Disease

DOI: 10.1021/jm00018a025

Source and publish data:

Journal of Medicinal Chemistry p. 3645 - 3651 (1995)

Update date:2022-07-31

Topics:

Authors:

Fink, David M.

Bores, Gina M.

Effland, Richard C.

Huger, Francis P.

Kurys, Barbara E.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00018a025

A series of 5-amino-5,6,7,8-tetrahydroquinolinones was designed and synthesized as acetylcholinesterase inhibitors.The compounds are related to hyperzine A, a naturally occurring cholinesterase inhibitor.They inhibit acetylcholinesterase in vitro, and man

Full text of DOI:10.1021/jm00018a025

Products guided by the article

Product name:2(1H)-Quinolinone, 5-[[2-(3,4-dichlorophenyl)ethyl]imino]-5,6,7,8-tetrahydro-1-propyl-

Cas No:143232-92-2

R&D Labs maybe for 143232-92-2

Evershine Chemical CO Ltd

Contact:+86-571-87010026

Address:202, Zhenhua Road,
Yueyang Hudex Pharmaceuticals Ltd.

Contact:0730-8748800

Address:Wujiang Bridge，Yueyang Economy & Technology Development Zone
HANGZHOU ZHONGCHANG SCIENTIFIC CO.,LTD

Contact:+86-571-88932183

Address:Hangzhou
Hubei Vanz Pharm Co.,Ltd

website:http://www.vanzpharm.com/en/index.html

Contact:86-27-84492310

Address:FANHU INDUSTRY PARK
Shenzhen Sunrising Industry Co., ltd.

Contact:+86 755 86571158 / 86571159 / 86571160

Address:2108 ZHENYE INT. BUSINESS CENTER,NO.3101-90 QIANHAI RD, NANSHAN,SHENZHEN, CHINA

Relevant to this article

Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2- methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists

Doi:10.1021/jm400275h
(2013)
Synthesis of 4-(ω-aminoalkyl)- or 4-(ω-lactamiminoalkyl)thiazoles by ring chain transformation of isothioureas with lactam derivatives

Doi:10.1055/s-1992-26197
(1992)
Discovery of a Novel Class of Orally Active, Non-Peptide Angiotensin II Antagonists

Doi:10.1021/jm00098a018
(1992)
Monomeric Cinchona Alkaloid-Based Catalysts for Highly Enantioselective Bromolactonisation of Alkynes

Doi:10.1002/chem.201604003
(2016)
Highly efficient divergent synthesis of dendrimers via metal-free click chemistry

Doi:10.1002/pola.26511
(2013)
Rearrangements and addition reactions of biarylazacyclooctynones and the implications to copper-free click chemistry

Doi:10.1039/c3ob40683k
(2013)

Article Doi