
Tetrahedron Letters p. 3715 - 3716 (1992)
Update date:2022-08-04
Topics:
Hauske, James R.
Dorff, Peter
Julin, Susan
Martinelli, Gary
Bussolari, Jacqueline
Exposure of chiral amino aldehydes (1) to dimethyl diazophosphonate (4) affords propargylic amines (2) of high optical purity.Chain extension of these intermediates is readily accomplished via hydrozirconation of the acetylene moiety and subsequent Ni(II) catalyzed Michael addition to a variety of Michael acceptors.
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