Preparation and Reactions of Chiral Propargylic Amines

DOI: 10.1016/0040-4039(92)80006-6

Source and publish data:

Tetrahedron Letters p. 3715 - 3716 (1992)

Update date:2022-08-04

Topics:

Authors:

Hauske, James R.

Dorff, Peter

Julin, Susan

Martinelli, Gary

Bussolari, Jacqueline

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Article abstract of DOI:10.1016/0040-4039(92)80006-6

Exposure of chiral amino aldehydes (1) to dimethyl diazophosphonate (4) affords propargylic amines (2) of high optical purity.Chain extension of these intermediates is readily accomplished via hydrozirconation of the acetylene moiety and subsequent Ni(II) catalyzed Michael addition to a variety of Michael acceptors.

Full text of DOI:10.1016/0040-4039(92)80006-6

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