Synthesis of antiviral nucleosides from crotonaldehyde. Part 3. Total synthesis of didehydrodideoxythymidine (d4T)

DOI: 10.1016/S0040-4039(00)74799-X

Source and publish data:

Tetrahedron Letters p. 3841 - 3844 (1992)

Update date:2022-09-26

Topics:

Authors:

Jung Jung

Gardiner

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Article abstract of DOI:10.1016/S0040-4039(00)74799-X

The total synthesis of the antiviral agent d4T 3 from the epoxyalcohol 2, itself derived from crotonaldehyde 1, in 6 steps and 18% overall yield is described.

Full text of DOI:10.1016/S0040-4039(00)74799-X

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