A synthesis of the tetraene fragment of calyculins as its antipodal form

Article abstract of DOI:10.1016/S0040-4039(00)74685-5

The antipodal form 2 of the tetraene fragment, the C1-C12 portion, of calyculins (1) has been synthesized by use of the stereoselective hydrogenation of the butenolide 6 followed by the successive Wittig-type chain elongation of the lactol 9 as key steps.