Synthesis and biological activity of peptide hydroxamate inhibitors of degradation of substance P analogues

Article abstract of DOI:10.1016/0223-5234(92)90001-H

A series of hydroxamic acid derivatives of peptides related to fragments of substance P (SP) were synthesized.Methyl, ethyl or N-hydroxy-succinimide ester precursors of the desired peptides were prepared by using classical peptide synthesis methodology an