Antioxidant, tautomerism and antibacterial studies of Fe(III)-1,2,4- triazole based complexes

Article abstract of DOI:10.1016/j.saa.2013.03.068

New Fe(III) complexes have been synthesized by the reactions of ferric nitrate with Schiff base derived from 3-substituted phenyl-4-amino-5-hydrazino- 1,2,4-triazole and indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non-electrolytes. Elemental analyses suggest that the complexes have 1:1 stoichiometry of the type [FeL_n(H₂O)(OH)]xH₂O. Structural and spectroscopic properties have been studied on the basis of elemental analyses, infrared spectra, ¹H and ¹³H NMR spectra, electronic spectra, magnetic measurements and FAB mass spectra. FT-IR, ¹H and ¹³H NMR studies reveal that the ligand (L_n) exists in the tautomeric enol form in both the states with intramolecular hydrogen bonding. Magnetic moment and reflectance spectral studies reveal that an octahedral geometry has been assigned to all the prepared complexes. FRAP values indicate that all the compounds have a ferric reducing antioxidant power. The compounds 2 and 3 showed relatively high antioxidant activity while compound 1 and 4 shows poor antioxidant power. Also good antimicrobial activities of the complexes against Staphylococcus aureus, Bacillus subtilis, Serratia marcescens, Pseudomonas aeruginosa and Escherichia coli have been found compared to its free ligands.