Inhibition of hog liver folylpolyglutamate synthetase by 5-substituted 5,8-dideaza analogues of folic acid bearing a terminal L-ornithine residue

Article abstract of DOI:10.1021/jm00100a013

Five new N(α)-(5,8-dideazapteroyl)-L-ornithines have been prepared using multistep synthetic sequences. These include N(α)-[5-(trifluoromethyl)-5,8- dideazapteroyl]-L-ornithine, 3, as well as N(α)-[5-(trifluoromethyl)-5,8- dideazaisopteroyl]-L-ornithine,