ENANTIOMERICALLY PURE OXYGENATED 1-PHENYLETHYLAMINES FROM SUBSTITUTED ACETOPHENONES: BY REDUCTIVE AMINATION AND REGIOSPECIFIC CLEAVAGE

DOI: 10.1016/S0040-4039(00)95189-X

Source and publish data:

Tetrahedron Letters p. 317 - 320 (1989)

Update date:2022-07-30

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Authors:

Bringmann, Gerhard

Geisler, Joerg-Peter

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Article abstract of DOI:10.1016/S0040-4039(00)95189-X

An efficient method for the asymmetric synthesis of chiral, oxygenated 1-phenylethylamines (1) in essentially two steps is described.The substituted acetophenones 2 are reductively aminated with unsubstituted chiral 1-phenylethylamine ("PEA",3), via the c

Full text of DOI:10.1016/S0040-4039(00)95189-X

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