Antimitotic agents: Ring analogues and derivatives of ethyl [(S)-5-amino- 1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl]carbamate

Article abstract of DOI:10.1021/jm00104a005

The synthesis of ring analogues and derivatives of the S isomer of ethyl [5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl]carbamate, (S)-1, a potent antimitotic agent with anticancer activity, was directed toward the determination of the co