Synthesis of fluorinated chirons: Stereoselective oxirane formation by reaction of diazomethane on 1-fluoro-3-arylsulfinyl-2-propanone and ring opening by selected nucleophiles

DOI: 10.1016/0040-4020(95)00430-G

Source and publish data:

Tetrahedron p. 8289 - 8310 (1995)

Update date:2022-07-30

Topics:

Authors:

Arnone, Alberto

Bravo, Pierfrancesco

Frigerio, Massimo

Salani, Giuliana

Viani, Fiorenza

Zappala, Carmela

Cavicchio, Giancarlo

Crucianelli, Marcello

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Article abstract of DOI:10.1016/0040-4020(95)00430-G

(R)-1-fluoro-3-[(4-methylphenyl)sulfinyl]-2-propanone (1) reacts with diazomethane affording (S)-2-(fluoromethyl)-2-{[(R)-(4-methylphenyl)sulfinyl]methyl}oxirane (2) as the main product. The influence of reaction conditions (solvent, temperature) on the c

Full text of DOI:10.1016/0040-4020(95)00430-G

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Product name:(S)-1-(benzylamino)-3-fluoro-2-(<(R)-(4-methylphenyl)sulfinyl>methyl)-2-propanol

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