The total synthesis of antrimycin D(v); II: Synthesis of tetrahydropyridazinecarboxylic acid and its incorporation into peptides

Article abstract of DOI:10.1055/s-1993-25947

Appropriately protected di- and tripeptides containing (R,S)-tetrahydropyridazine-3-carboxylic acids were synthesized via protected γ-formyl-α-hydrazinobutyric acids. The latter compounds are obtained from acetals of either ethyl γ-formylbutyrate or ethyl γ-formyl-α-oxobutyrate.