DNA cleavage by neocarzinostatin chromophore. Establishing the intermediacy of chromophore-derived cumulene and biradical species and their role in sequence-specific cleavage

DOI: 10.1021/ja00084a007

Source and publish data:

Journal of the American Chemical Society p. 1670 - 1682 (1994)

Update date:2022-08-04

Topics:

Authors:

Myers, Andrew G.

Cohen, Scott B.

Kwon, Byoung-Mog

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/ja00084a007

Experiments establishing the intermediacy of the cumulene 3 and the biradical 4 in the cleavage of double-stranded DNA by neocarzinostatin chromophore (1) and methyl thioglycolate (2) are described. It is shown that, in the presence of millimolar concentr

Full text of DOI:10.1021/ja00084a007

Products guided by the article

Product name:diethyl 3,6-dihydrophthalate

Cas No:14503-20-9

R&D Labs maybe for 14503-20-9

Synochem Ingredients Corp., Ltd.

Contact:+86-512-5636 2180

Address:Zhangjiagang Free Trade Zone
Golden Union Agrochemical Import and Export Co., Ltd.

Contact:86-755-23910527

Address:Room 1106, Tower 3A, Excellence Century Center, Futian District, Shenzhen, China
Zhejiang Genebest Pharmaceutical Co.,Ltd.

Contact:0086-571-63532866

Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Zipont chem(wuhan）Tech co.，Ltd

Contact:+86-27-87587198

Address:wuhan
SHANDONG CREDAGRI CHEMICAL CO., LTD.

Contact:+86-531-88872050

Address:ROOM 601A, BUILDING 2, SHUNTAI SQUARE, NO. 2000 SHUNHUA ROAD, HI-TECH DEVELOPMENT ZONE, JINAN, CHINA.

Relevant to this article

Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH

Doi:10.1016/j.bmcl.2013.07.016
(2013)
Domino Michael/Mannich/ N-alkylation route to the tetrahydrocarbazole framework of Aspidosperma alkaloids: Concise total syntheses of (-)-aspidospermidine, (-)-tabersonine, and (-)-vincadifformine

Doi:10.1021/ja408114u
(2013)
Construction of dispirocyclopentanebisoxindoles via self-domino michael-aldol reactions of 3-phenacylideneoxindoles

Doi:10.1021/jo4010603
(2013)
Regioselective synthesis of 4-acetyl- and 5-acetyl-3-methylisoxazole: Their conversion into silyl- and methyl enol ethers

Doi:10.1080/00397919208021114
(1992)
Identification of a unique glutathione conjugate of trichloroacrolein using heteronuclear multiple quantum coherence ¹³C nuclear magnetic resonance spectroscopy

Doi:10.1021/ja00165a068
(1990)
Regio- and stereoselective synthesis of 1,3-hydroxyl amines via palladium-catalyzed carbonate-carbamate transformation with unique stereoselectivity: Synthesis of 3-amino-4-penten-1-ols

Doi:10.1021/jo00085a039
(1994)

Article Doi