DNA cleavage by neocarzinostatin chromophore. Establishing the intermediacy of chromophore-derived cumulene and biradical species and their role in sequence-specific cleavage

DOI: 10.1021/ja00084a007

Source and publish data:

Journal of the American Chemical Society p. 1670 - 1682 (1994)

Update date:2022-08-04

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Authors:

Myers, Andrew G.

Cohen, Scott B.

Kwon, Byoung-Mog

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Article abstract of DOI:10.1021/ja00084a007

Experiments establishing the intermediacy of the cumulene 3 and the biradical 4 in the cleavage of double-stranded DNA by neocarzinostatin chromophore (1) and methyl thioglycolate (2) are described. It is shown that, in the presence of millimolar concentr

Full text of DOI:10.1021/ja00084a007

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